{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T07:33:46Z","timestamp":1765438426996},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,27]],"date-time":"2016-03-27T00:00:00Z","timestamp":1459036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to investigate the safety, tolerability and pharmacokinetics of coadministered azithromycin (AZI) and piperaquine (PQ) for treating malaria in pregnant Papua New Guinean women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty pregnant women (median age 22\u00a0years; 16\u201332\u00a0weeks' gestation) were given three daily doses of 1\u00a0g AZI plus 960\u00a0mg PQ tetraphosphate with detailed monitoring\/blood sampling over 42\u00a0days. Plasma AZI and PQ were assayed using liquid chromatography\u2013mass spectrometry and high\u2010performance liquid chromatography, respectively. Pharmacokinetic analysis was by population\u2010based compartmental models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The treatment was well tolerated. The median (interquartile range) increase in the rate\u2010corrected electrocardiographic QT interval 4\u00a0h postdose [12 (6\u201326) ms<jats:sup>0<\/jats:sup><jats:sup>.5<\/jats:sup>] was similar to that found in previous studies of AZI given in pregnancy with other partner drugs. Six women with asymptomatic malaria cleared their parasitaemias within 72\u00a0h. Two apararasitaemic women developed late uncomplicated <jats:italic>Plasmodium falciparum<\/jats:italic> infections on Days 42 and 83. Compared with previous pregnancy studies, the area under the concentration\u2013time curve (AUC<jats:sub>0\u2013\u221e<\/jats:sub>) for PQ [38818 (24354\u201352299) \u03bcg h l<jats:sup>\u22121<\/jats:sup>] was similar to published values but there was a 52% increase in relative bioavailability with each dose. The AUC<jats:sub>0\u2013\u221e<\/jats:sub> for AZI [46799 (43526\u201349462) \u03bcg h l<jats:sup>\u22121<\/jats:sup>] was at least as high as reported for higher\u2010dose regimens, suggesting saturable absorption and\/or concentration\u2010dependent tissue uptake and clearance from the central compartment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AZI\u2013PQ appears to be well tolerated and safe in pregnancy. Based on the present\/other data, total AZI doses higher than 3\u00a0g for the treatment and prevention of malaria may be unnecessary in pregnant women, while clearance of parasitaemia could improve the relative bioavailability of PQ.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12910","type":"journal-article","created":{"date-parts":[[2016,2,18]],"date-time":"2016-02-18T14:40:28Z","timestamp":1455806428000},"page":"199-212","source":"Crossref","is-referenced-by-count":20,"title":["Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women"],"prefix":"10.1111","volume":"82","author":[{"given":"Brioni R.","family":"Moore","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia  Crawley Western Australia Australia"},{"name":"Papua New Guinea Institute of Medical Research  Madang Madang Province Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research  Madang Madang Province Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siu On","family":"Auyeung","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Salman","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gumul","family":"Yadi","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research  Madang Madang Province Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Griffin","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research  Madang Madang Province Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Page\u2010Sharp","sequence":"additional","affiliation":[{"name":"School of Pharmacy Curtin University of Technology  Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin T.","family":"Batty","sequence":"additional","affiliation":[{"name":"School of Pharmacy Curtin University of Technology  Bentley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Siba","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research  Madang Madang Province Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Mueller","sequence":"additional","affiliation":[{"name":"Infection and Immunity Walter and Eliza Hall Institute  Melbourne Victoria Australia"},{"name":"Barcelona Institute for Global Health (ISGLOBAL)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Rogerson","sequence":"additional","affiliation":[{"name":"Department of Medicine (RMH) The University of Melbourne  Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy ME","family":"Davis","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology The University of Western Australia  Crawley Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70021-X"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.10.113"},{"key":"e_1_2_9_4_1","volume-title":"Guidelines for the treatment of malaria. 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