{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:44:35Z","timestamp":1789029875445,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T00:00:00Z","timestamp":1463788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched 14 electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals. Additional publications were identified from manually searching textbooks, conference abstracts and the grey literature. All study designs were included as long as they contained clinical information. These gathered findings were summarized narratively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010two publications met inclusion criteria. These reported on 10 herbal and dietary supplements. Overall evidence linking haemolysis to a herbal\/dietary supplement was only found for henna. No evidence of harm was observed for vitamin C, vitamin E, vitamin K, <jats:italic>Gingko biloba<\/jats:italic> and <jats:italic>\u03b1<\/jats:italic>\u2010lipoic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The review showed that there was insufficient evidence to contravene the use of most herbal or dietary products at therapeutic doses in G6PD deficient subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.12976","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T22:56:41Z","timestamp":1460761001000},"page":"172-179","source":"Crossref","is-referenced-by-count":34,"title":["Adverse effects of herbal or dietary supplements in G6PD deficiency: a systematic review"],"prefix":"10.1111","volume":"83","author":[{"given":"Shaun Wen Huey","family":"Lee","sequence":"first","affiliation":[{"name":"School of Pharmacy Monash University Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai Ming","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Medicine Taylor's University  Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathorn","family":"Chaiyakunapruk","sequence":"additional","affiliation":[{"name":"School of Pharmacy Monash University Malaysia"},{"name":"Center of Pharmaceutical Outcomes Research (CPOR), Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences Naresuan University  Phitsanulok Thailand"},{"name":"School of Pharmacy University of Wisconsin  Madison USA"},{"name":"School of Population Health University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Weng Kwai","family":"Chong","sequence":"additional","affiliation":[{"name":"School of Pharmacy International Medical University  Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.12.005"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb13216.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.11.3613.bloodjournal84113613"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536520-000000000-00000"},{"key":"e_1_2_10_6_1","first-page":"1277","article-title":"Diagnosis and management of G6PD deficiency","volume":"72","author":"Frank JE","year":"2005","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_7_1","unstructured":"Dietary supplements:National Institutes of Health Office of Dietary Supplements;2015.https:\/\/ods.od.nih.gov\/factsheets\/DietarySupplements-HealthProfessional\/(last accessed on 30 November 2015)."},{"key":"e_1_2_10_8_1","unstructured":"World Health Organization (WHO) \u2014 Uppsala Monitoring Centre.The use of the WHO\u2010UMC system for standardized case causality assessment. Available from:http:\/\/www.who-umc.org\/Graphics\/24734.pdf(last accessed on 30 November 2015)."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.85.5.411"},{"key":"e_1_2_10_10_1","first-page":"556","article-title":"Singapore kernicterus","volume":"21","author":"Wong HB","year":"1980","journal-title":"Singapore Med J"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-82-6-810_1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.6.F534"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.05.042"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1996.11747840"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00048.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.97.5.707","article-title":"Henna: a potential cause of oxidative hemolysis and neonatal hyperbilirubinemia","volume":"97","author":"Zinkham WH","year":"1996","journal-title":"Pediatrics"},{"key":"e_1_2_10_17_1","first-page":"119","article-title":"Henna induced severe hemolysis in glucose\u20106\u2010phosphate dehydrogenase deficiency","volume":"23","author":"Seyedzadeh A","year":"2007","journal-title":"Pak J Med Sci"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02306.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)92317-B"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.306.6881.841"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.954124"},{"key":"e_1_2_10_22_1","article-title":"Antioxidant vitamins and hyperbilirubinemia in neonates","volume":"5","author":"Abdul\u2010Razzak KK","year":"2007","journal-title":"Ger Med Sci"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030802"},{"key":"e_1_2_10_24_1","first-page":"12","article-title":"Effects of vitamin E supplementation on some aspects of hematological variables in patients of hemolytic anemia with glucose 6 phosphate dehydrogenase (G6PD) deficiency","volume":"22","author":"Sultana N","year":"2006","journal-title":"Bangladesh J Physiol Pharmacol"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1982.tb31274.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198304283081708"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(79)80078-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-1-53"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80833-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.79.3.F218"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)93059-9"},{"key":"e_1_2_10_32_1","first-page":"420","article-title":"Effect of vitamin K and naphthalene metabolites on gluthathione metabolism of erythrocytes from normal newborns and patients with napthalene hemolytic anemia","volume":"94","author":"Zinkham WH","year":"1957","journal-title":"Am J Dis Child"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0121.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350599"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.01.055"},{"key":"e_1_2_10_36_1","first-page":"95","article-title":"Severe haemolysis in a G6PD deficient individual following intake of \u2018Mentat\u2019","volume":"31","author":"Sharma N","year":"1997","journal-title":"Bulletin, Postgraduate Institute of Medical Education and Research, Chandigarh"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)92314-2"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.10.040"},{"key":"e_1_2_10_39_1","unstructured":"SellahewaKH.Clinical study of intravascular haemolysis at Anurahapura. Sri Lanka Medial Association Annual Session1992:20."},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4172\/2325-9841.1000116"},{"key":"e_1_2_10_41_1","first-page":"46","article-title":"Acalypha indica\n                   Induced haemolysis in G6PD deficiency","volume":"39","author":"Lamabadusuriya SP","year":"1994","journal-title":"Ceylon Med J"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/004947559602600113"},{"key":"e_1_2_10_43_1","first-page":"97","article-title":"Acute and subacute toxicity studies of ethanolic extract of \n                     Acalypha indica\n                   Linn in male Wistar albino rats","volume":"5","author":"Sathya M","year":"2012","journal-title":"Asian J Pharm Clin Res"},{"key":"e_1_2_10_44_1","first-page":"149","article-title":"Acute massive haemolysis in children with glucose\u20106\u2010phosphate dehydrogenase deficiency","volume":"12","author":"Lau HK","year":"2006","journal-title":"Hong Kong Med J"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3617"},{"key":"e_1_2_10_46_1","first-page":"180","article-title":"Severe hyperbilirubinaemia associated with Chinese herbs. A case report","volume":"38","author":"Yeo KL","year":"1996","journal-title":"Singapore Paediatr J"},{"key":"e_1_2_10_47_1","first-page":"2543","article-title":"Investigation of Coptis chinensis on jaundice of glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficient neonates from Guigang,","volume":"32","author":"Lin N","year":"2007","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.23.2868"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.08.021"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60073-2"},{"key":"e_1_2_10_51_1","first-page":"601","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency","volume":"67","author":"WHO Working Group","year":"1989","journal-title":"Bull World Health Organ"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.12976","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.12976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T07:42:28Z","timestamp":1694590948000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.12976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,21]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/bcp.12976"],"URL":"https:\/\/doi.org\/10.1111\/bcp.12976","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,21]]}}}