{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:01Z","timestamp":1787013901296,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study characterized the pharmacokinetics of ramosetron and compared prophylactic anti\u2010emetic efficacy with that of ondansetron in a large population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010eight patients consented to the pharmacokinetic analysis and were assigned randomly to receive 0.3, 0.45 or 0.6\u00a0mg ramosetron after induction of anaesthesia. Blood samples were acquired at preset intervals. Non\u2010compartmental and population pharmacokinetic analyses were performed. In total, 1102 patients consented to the evaluation of prophylactic anti\u2010emetic efficacy and were allocated randomly to receive 0.3\u00a0mg ramosetron or 4\u00a0mg ondansetron at the end of surgery. An additional 16\u00a0mg ondansetron were mixed in the intravenous patient\u2010controlled analgesia pump of the ondansetron group. Post\u2010operative nausea and vomiting (PONV) were evaluated 6, 24 and 48\u00a0h post\u2010operatively using the Rhodes index of nausea, vomiting and retching (RINVR). Administration of rescue anti\u2010emetics and adverse events were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The pharmacokinetic parameter estimates were\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      (l)\u00a0=\u00a05.12,\n                      <jats:italic>V<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      (l)\u00a0=\u00a0108, CL (l\u22c5min\n                      <jats:sup>\u22121<\/jats:sup>\n                      )\u00a0=\u00a00.08\u00a0+\u00a0(59\u22c5age\n                      <jats:sup>\u22121<\/jats:sup>\n                      )\u00a0\u00d7\u00a00.09, Q (l\u22c5min\n                      <jats:sup>\u22121<\/jats:sup>\n                      )\u00a0=\u00a01.42. The incidences of PONV in the ramosetron and ondansetron groups were 77 (13.9%) and 113 (20.6%) and 44 (7.9%) and 66 (12.0%) at 24 and 48\u00a0h post\u2010operatively, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.004, 0.030). RINVR was significantly lower in the ramosetron than the ondansetron group 24 and 48\u00a0h post\u2010operatively (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003, 0.025). Use of rescue anti\u2010emetics and incidence of adverse events were comparable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A two compartment mammillary model was used to describe ramosetron pharmacokinetics. Prophylactic anti\u2010emetic efficacy of ramosetron was significantly better 24 and 48\u00a0h post\u2010operatively than that of ondansetron, particularly when the Apfel score was\u00a0\u2265\u00a03.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.13010","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T23:08:38Z","timestamp":1463699318000},"page":"762-772","source":"Crossref","is-referenced-by-count":8,"title":["Population pharmacokinetics and prophylactic anti\u2010emetic efficacy of ramosetron in surgical patients"],"prefix":"10.1111","volume":"82","author":[{"given":"Yong\u2010Hun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine, Asan Medical Centre University of Ulsan College of Medicine  Seoul"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Hyeon","family":"Seo","sequence":"additional","affiliation":[{"name":"Intern, Asan Medical Centre  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