{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:57:32Z","timestamp":1790081852209,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>This prospective study aimed to characterize the population pharmacokinetics of intravenous oxycodone and to determine the minimum effective concentration (MEC) and minimum effective analgesic concentration (MEAC) of oxycodone for major open intra\u2010abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the pharmacokinetic study, patients were administered intravenous oxycodone (0.1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>), and arterial blood was sampled at pre\u2010set intervals. In the analgesic\u2010potency study, patients were administered intravenous oxycodone (0.1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>) 30\u00a0min before the end of the surgery, were placed in the postoperative anaesthesia care unit (PACU), and were asked to rate their pain every 10\u00a0min using a visual analogue scale (0 = no pain, 10 = most severe pain). On the first occasion that wound pain at rest and during compression was rated as \u22653 or \u22655, respectively, the first blood sample was obtained to determine the MEC. A second blood sample was obtained after titration with 2\u00a0mg of oxycodone to yield wound pain &lt;3 at rest and &lt;5 during wound compression, and MEAC was determined. MEC and MEAC were determined again in each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the population pharmacokinetic study (<jats:italic>n<\/jats:italic>\u00a0=\u00a054), oxycodone plasma concentration over time was well described by a three\u2010compartment mammillary model. Lean body mass and age were significant covariates for the volume of distribution and metabolic clearance of the pharmacokinetic model of oxycodone, respectively. The analgesic\u2010potency study (<jats:italic>n<\/jats:italic>\u00a0=\u00a050) showed that the median (95% CI) MEC and MEAC were 31.5 (19.2\u201342.8) and 74.1 (29.2\u2013128.3) ng\u00a0ml<jats:sup>\u22121<\/jats:sup> (first measurements) and 63.4 (15.6\u2013120.1) and 76.1 (32.9\u2013132.7) ng\u00a0ml<jats:sup>\u22121<\/jats:sup> (second measurements), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In major intra\u2010abdominal open surgery, the MEAC and analgesic potency of oxycodone were 75\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup> and 60\u00a0ng\u00a0ml<jats:sup>\u22121<\/jats:sup>, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13101","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T08:06:39Z","timestamp":1472112399000},"page":"314-325","source":"Crossref","is-referenced-by-count":33,"title":["Population pharmacokinetics and analgesic potency of oxycodone"],"prefix":"10.1111","volume":"83","author":[{"given":"Byung\u2010Moon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Mee","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Drug Safety Evaluation New Drug Development Center Osong Medical Innovation Foundation  Chungju\u2010si Chungbuk Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun\u2010Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics Ewha Women's University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu\u2010Jeong","family":"Noh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"},{"name":"Department of Clinical Pharmacology and Therapeutics, Asan Medical Centre University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13348"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0036-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12586"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/11586140-000000000-00000"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aer395"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00709.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270006286433"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00839.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01819.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200002000-00021"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199701000-00004"},{"key":"e_1_2_10_14_1","unstructured":"BealS SheinerL.NONMEM User's Guides. Part V. Introductory Guide. San Francisco: NONMEM Project Group University of California 1994."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710223171717"},{"key":"e_1_2_10_16_1","first-page":"1016","article-title":"Determination of ideal body weight for drug dosage calculations","volume":"40","author":"Robinson JD","year":"1983","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1981.tb01163.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.133"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200406000-00007"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100241"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011527125570"},{"key":"e_1_2_10_22_1","unstructured":"JamesWPT WaterlowJC.UK Department of Health and Social Security\/Medical Research Council Group on Obesity Research. Research on obesity: a report of the DHSS\/MRC Group. London: Her Majesty's Stationery Office 1976."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317690-000000000-00000"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.136986"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544100-00004"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2016.69.3.211"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2000.01374.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-015-0107-7"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060239"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60388-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2008.01650.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199711000-00010"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0345-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009165"},{"key":"e_1_2_10_35_1","first-page":"143","article-title":"The modifying effect of anesthetic technique on the metabolic and endocrine responses to anesthesia and surgery","volume":"39","author":"Kehlet H","year":"1988","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000165"},{"key":"e_1_2_10_37_1","first-page":"445","article-title":"Clinical interpretation of pharmacokinetic and pharmacodynamic propofol\u2010opioid interactions","volume":"52","author":"Vuyk J","year":"2001","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/65.3.353"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(00)00271-X"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(97)90100-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2006.01.009"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:40:11Z","timestamp":1695516011000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/bcp.13101"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13101","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}