{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:15:42Z","timestamp":1695528942661},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,16]],"date-time":"2016-10-16T00:00:00Z","timestamp":1476576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the current study was to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of cisatracurium in patients with severe mitral valve regurgitation (MR) during the anaesthetic induction period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients in the clinical trial were divided into two groups: the MR group (<jats:italic>n<\/jats:italic> = 15) and the control group (<jats:italic>n<\/jats:italic> = 15). Arterial blood samples were obtained before (time 0) and at 1, 2, 4, 6, 8, 10, 15 and 20\u00a0min after intravenous injection of 0.15\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> cisatracurium. The degree of neuromuscular block was measured by train of four (TOF) testing. The concentration of cisatracurium in the plasma was determined by high\u2010performance liquid chromatography. A conventional two\u2010compartment model and integrated PK\/PD model were applied to PK and PD data analysis, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of PK model fitting demonstrated that severe MR reduced the distribution rate of cisatracurium from the central to peripheral compartment, resulting in a higher concentration of the drug in the plasma. The time to the maximal neuromuscular blocking effect of cisatracurium was delayed in the MR group (2.08\u00a0min in the control group <jats:italic>vs<\/jats:italic>. 4.12\u00a0min in the MR group). The PK\/PD model indicated that the distribution rate of cisatracurium from the blood to the effect compartment was decreased in the MR group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study suggested that the PK and PD of cisatracurium were significantly altered in patients with severe MR. The study has the potential to improve the safety of anaesthetic induction in patients with severe MR through accurate prediction of the PD responses of cisatracurium using the established PK\/PD model.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13121","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T01:42:54Z","timestamp":1472694174000},"page":"363-369","source":"Crossref","is-referenced-by-count":2,"title":["Altered pharmacodynamics and pharmacokinetics of cisatracurium in patients with severe mitral valve regurgitation during anaesthetic induction period"],"prefix":"10.1111","volume":"83","author":[{"given":"Jiayi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Department of Anesthesiology Guangzhou Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou 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