{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:04:16Z","timestamp":1783451056364,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Cetuximab is an anti\u2010epidermal growth factor receptor antibody used for the treatment of metastatic colorectal cancer and head and neck cancer. Hypersensitivity reactions (HSRs) are associated with cetuximab use. The aim of the study was to evaluate the utility of anti\u2010cetuximab immunoglobulin E (IgE) detection in order to identify patients at risk of HSR to cetuximab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients ready to receive a first cetuximab infusion in a prospective cohort carried out at nine French centres. Pretreatment anti\u2010cetuximab IgE levels were measured. We compared the proportion of severe HSRs in the low anti\u2010cetuximab IgE levels (\u226429 IgE arbitrary units) subgroup with that in a historical cohort of 213 patients extracted from a previous study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 301 assessable patients (mean age: 60.9\u00a0\u00b1\u00a09.3\u00a0years, head\u2010and\u2010neck cancer: 77%), 66 patients (22%) had high anti\u2010cetuximab IgE levels, and 247 patients received cetuximab (including 38 with high anti\u2010cetuximab levels). Severe HSRs occurred in eight patients (five grade 3 and three grade 4). The proportion of severe HSRs was lower in the low anti\u2010cetuximab IgE levels subgroup <jats:italic>vs.<\/jats:italic> the historical cohort (3\/209 [1.4%] <jats:italic>vs.<\/jats:italic> 11\/213 [5.2%], odds ratio, 0.27, 95% confidence interval, 0.07\u20130.97), and higher in high <jats:italic>vs.<\/jats:italic> low anti\u2010cetuximab IgE levels subgroup (5\/38 [13.2%] <jats:italic>vs.<\/jats:italic> 3\/209 [1.4%]; odds ratio, 10.4, 95% confidence interval, 2.4\u201345.6). Patients with severe HSRs had higher anti\u2010cetuximab IgE levels than patients without reaction (median, 45 <jats:italic>vs.<\/jats:italic> 2 IgE arbitrary units, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Detection of pretreatment anti\u2010cetuximab IgE is feasible and helpful to identify patients at risk of severe cetuximab\u2010induced HSRs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13140","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T08:02:41Z","timestamp":1474704161000},"page":"623-631","source":"Crossref","is-referenced-by-count":21,"title":["Utility of serum anti\u2010cetuximab immunoglobulin E levels to identify patients at a high risk of severe hypersensitivity reaction to cetuximab"],"prefix":"10.1111","volume":"83","author":[{"given":"Beno\u00eet","family":"Dupont","sequence":"first","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology and Nutrition CHU de Caen  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Mariotte","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Immunopathology CHU de Caen  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey E.","family":"Dugu\u00e9","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Clarisse","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Fran\u00e7ois Baclesse  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Michel","family":"Grellard","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Fran\u00e7ois Baclesse  Caen 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