{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:03:00Z","timestamp":1777525380036,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate the efficacy of olanzapine for the prevention of chemotherapy\u2010induced nausea and vomiting (CINV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The literature was searched for randomized controlled trials (RCTs) evaluating the efficacy of olanzapine for the prophylaxis of CINV using PubMed, Embase, Central, as well as <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link> for unpublished studies. The endpoints of the study were the number of patients who achieved a complete response (CR; no emesis and no rescue) and no nausea in the acute, delayed and overall phases. Two authors independently selected studies, assessed the risk of bias and extracted data. The included RCTs were analysed using RevMan 5.3 provided by the Cochrane Collaboration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten RCTs were identified for the meta\u2010analysis. Compared with other antiemetic agents, olanzapine significantly improved the CR in the delayed and overall phases, but did not enhance the CR in the acute phase. For the control of CINV, olanzapine was better than and comparable with aprepitant in the acute phase and delayed phase, respectively. Compared with placebo, treatment with 5\u00a0mg and 10\u00a0mg olanzapine exhibited similar efficacy in terms of the CR in the delayed and overall phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Olanzapine is an excellent alternative for the prophylaxis of CINV. Olanzapine 5\u00a0mg per day should be recommended as the initial dose because of equivalent efficacy to a 10\u00a0mg dose but a lower potential risk of side effects. Further studies are needed to explore the optimal combination of medicines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13242","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T11:52:56Z","timestamp":1485172376000},"page":"1369-1379","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy of olanzapine for the prophylaxis of chemotherapy\u2010induced nausea and vomiting: a meta\u2010analysis"],"prefix":"10.1111","volume":"83","author":[{"given":"Ting","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences Peking University Health Science Center  38 Xueyuan Street, Haidian District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences Peking University Health Science Center  38 Xueyuan Street, Haidian District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimin","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Peking University First Hospital  6 Dahongluochang Street, Xicheng District Beijing 100034 China"},{"name":"Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences Peking University Health Science Center  38 Xueyuan Street, Haidian District Beijing 100034 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13348"},{"key":"e_1_2_8_4_1","first-page":"637","article-title":"Practical management of chemotherapy\u2010induced nausea and vomiting","volume":"19","author":"Wiser W","year":"2005","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050078"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.11.1746"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.4614"},{"key":"e_1_2_8_8_1","unstructured":"National Comprehensive Cancer Network.NCCN guidelines antiemesis version 2 2016[online]. 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