{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T13:38:24Z","timestamp":1792330704264,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to assess the predictivity of laser\u2010(radiant\u2010heat)\u2010evoked potentials (LEPs) from the vertex electroencephalogram, using an algesimetric procedure, testing the anti\u2010nociceptive\/anti\u2010hyperalgesic effects of single oral doses of four marketed analgesics (of different compound classes) <jats:italic>vs.<\/jats:italic> placebo, in healthy volunteers with three skin types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, placebo\u2010controlled, single\u2010blind, five\u2010way\u2010crossover trial. Twenty\u2010five healthy male\/female Caucasians were included (receiving celecoxib 200\u00a0mg, pregabalin 150\u00a0mg, duloxetine 60\u00a0mg, lacosamide 100\u00a0mg or placebo) in a Williams design, with CO<jats:sub>2<\/jats:sub> laser\u2010induced painful stimuli to normal, ultraviolet (UV) B\u2010inflamed and capsaicin\u2010irritated skin. LEPs and visual analogue scale ratings were taken at baseline and hourly for 6\u00a0h postdose from all three skin types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal skin, the averaged postdose LEP peak\u2010to\u2010peak\u2010(PtP)\u2010amplitudes were reduced by pregabalin (\u22122.68\u00a0\u03bcV; 95% confidence interval (CI) \u22124.16, 1.19) and duloxetine (\u22121.73\u00a0\u03bcV; 95% CI \u22123.21, \u22120.26) but not by lacosamide and celecoxib <jats:italic>vs.<\/jats:italic> placebo. On UVB\u2010irradiated skin, reflecting inflammatory pain, celecoxib induced a pronounced reduction in LEP PtP amplitudes <jats:italic>vs.<\/jats:italic> placebo (\u22126.2\u00a0\u03bcV; 95% CI \u22127.88, \u22124.51), with a smaller reduction by duloxetine (\u22124.54\u00a0\u03bcV; 95% CI \u22126.21, \u22122.87) and pregabalin (\u22123.72\u00a0\u03bcV; 95% CI \u22125.40, \u22122.04), whereas lacosamide was inactive. LEP PtP amplitudes on capsaicin\u2010irritated skin, reflecting peripheral\/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (\u22123.78\u00a0\u03bcV; 95% CI \u22125.31, \u22122.25) and duloxetine (\u22122.32\u00a0\u03bcV; 95% CI \u22123.82, \u22120.82) but not by celecoxib or lacosamide <jats:italic>vs.<\/jats:italic> placebo, which was in agreement with known clinical profiles. Overall, PtP amplitude reductions were in agreement with subjective ratings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LEP algesimetry is sensitive to analgesics with different modes of action and may enable the effects of novel analgesics to be assessed during early clinical development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13247","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T08:17:04Z","timestamp":1485850624000},"page":"1424-1435","source":"Crossref","is-referenced-by-count":16,"title":["Investigation of the predictive validity of laser\u2010EPs in normal, UVB\u2010inflamed and capsaicin\u2010irritated skin with four analgesic compounds in healthy volunteers"],"prefix":"10.1111","volume":"83","author":[{"given":"Klaus","family":"Schaffler","sequence":"first","affiliation":[{"name":"HPR, Human Pharmacodynamic Research GmbH  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent B.","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Translational Medicine and Clinical Pharmacology Boehringer Ingelheim Pharma GmbH &amp; Co. 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