{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:52:55Z","timestamp":1791935575509,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aims of the current study were to determine the distribution of aetiologies for the drug\u2010induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) in hospitalized patients, and to characterize them according to the different drug groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre retrospective study was carried out, including all patients diagnosed with SIADH in a large community hospital and tertiary centre between 1 January 2007 and 1 January 2013 who were treated with drugs known to be associated with SIADH. Two physicians reviewed every patient's medical file for predetermined relevant clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 198 patients who had SIADH and received drugs associated with SIADH. Most patients [146 (73.7%)] were diagnosed with drug\u2010associated SIADH, while 52 (26.3%) were diagnosed with SIADH due to other aetiologies. The Naranjo algorithm differentiated well between the two groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Five drug classes (antidepressants, anticonvulsants, antipsychotic agents, cytotoxic agents and pain medications) were implicated in 82.3% of patients diagnosed with drug\u2010associated SIADH. Specific serotonin reuptake inhibitors and carbamazepine were commonly implicated. There were no clinically significant differences in the characteristics or severity of SIADH according to drug class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The clinical characteristics of SIADH caused by different drugs are comparable. Patients with SIADH treated with drugs from five common medication classes will probably be diagnosed with drug\u2010induced SIADH. Physicians should be aware of the significance of these medication classes as SIADH aetiologies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13256","type":"journal-article","created":{"date-parts":[[2017,2,7]],"date-time":"2017-02-07T09:46:43Z","timestamp":1486460803000},"page":"1801-1807","source":"Crossref","is-referenced-by-count":89,"title":["Medication\u2010induced SIADH: distribution and characterization according to medication class"],"prefix":"10.1111","volume":"83","author":[{"given":"Daniel","family":"Shepshelovich","sequence":"first","affiliation":[{"name":"Medicine A, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Schechter","sequence":"additional","affiliation":[{"name":"Medicine A, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronislava","family":"Calvarysky","sequence":"additional","affiliation":[{"name":"Medicine A, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Pharmacy Service, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"School of Pharmacy, the Faculty of Medicine Hebrew University  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Diker\u2010Cohen","sequence":"additional","affiliation":[{"name":"Medicine A, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Institute of Endocrinology, Diabetes and Metabolism, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benaya","family":"Rozen\u2010Zvi","sequence":"additional","affiliation":[{"name":"Department of Nephrology Rabin Medical Center  Petah\u2010Tikva Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Gafter\u2010Gvili","sequence":"additional","affiliation":[{"name":"Medicine A, Beilinson Hospital Rabin Medical Center  Petah Tikva Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90224-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp066837"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2013.07.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-1020e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.10.020"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11319070-000000000-00000"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.01.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1994.tb02930.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/11318950-000000000-00000"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.05.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00055-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G293"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2011.02297.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.03.004"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13256","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:55:42Z","timestamp":1694354142000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,2]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/bcp.13256"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13256","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,2]]}}}