{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:44:53Z","timestamp":1722930293166},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T00:00:00Z","timestamp":1492646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Antiplatelet drugs are often discontinued early after ischaemic stroke, either because of poor compliance, complications or withdrawal of care. It is unclear whether this places patients at increased risk of recurrence. We explored the association between cardiovascular event rate and persistence with prescribed antiplatelet drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a matched case\u2013control design using the Virtual International Stroke Trials Archive (VISTA). Cases were patients who had an acute coronary syndrome, recurrent stroke or transient ischaemic attack within 90\u00a0days post\u2010stroke and were matched for age\u00a0\u00b1\u00a010\u00a0years and sex with up to four controls. Antiplatelet use was categorized as persistent (used for &gt;3\u00a0days and continued up to day 90), early cessation (used antiplatelet &lt;3\u00a0days) or stopped\/interrupted users (used for &gt;3\u00a0days but stopped prior to day 90). These categories were compared in cases and controls using a conditional logistic regression model that adjusted for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 970 patients were included, of whom 194 were cases and 776 were matched controls. At 90\u00a0days, 10 cases (5.2%) and 58 controls (7.5%) stopped\/interrupted their antiplatelet. The risk of cardiovascular event was not different in stopped\/interrupted users (adjusted odds ratio 0.70, 95% confidence interval 0.33, 1.48; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.352) and early cessations (adjusted odds ratio 1.04, 95% confidence interval 0.62, 1.74; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.876) when compared to persistent users.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found no increased risk in patients who stopped and interrupted antiplatelets early after stroke but the study was limited by a small sample size and further research is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13290","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T07:36:45Z","timestamp":1489649805000},"page":"2045-2055","source":"Crossref","is-referenced-by-count":0,"title":["Interruption to antiplatelet therapy early after acute ischaemic stroke: a nested case\u2013control study"],"prefix":"10.1111","volume":"83","author":[{"given":"Wardati","family":"Mazlan\u2010Kepli","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow Queen Elizabeth University Hospital  Glasgow G51 4TF UK"},{"name":"Pharmacy Department Serdang Hospital  43000 Kajang Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachael L.","family":"Macisaac","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow Queen Elizabeth University Hospital  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Walters","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow Queen Elizabeth University Hospital  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Michael William","family":"Bath","sequence":"additional","affiliation":[{"name":"Stroke Trials Unit University of Nottingham  Nottingham NG7 2UH UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesse","family":"Dawson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow Queen Elizabeth University Hospital  Glasgow G51 4TF UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the VISTA Collaborators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1037"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13348"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13354"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13350"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13355"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13347"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069936"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3181f7d043"},{"key":"e_1_2_12_10_1","unstructured":"National Institute for Health and Clinical Excellence.Stroke: Diagnosis and initial management of acute stroke and transient ischaemic attack. 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