{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:52:02Z","timestamp":1790506322915,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The present study aims to describe real\u2010life outcomes in stable patients after\u2010myocardial infarction (MI) similar to those in the PEGASUS\u2010TIMI 54 trial (PEGASUS), which found long\u2010term benefits of ticagrelor in patients with a history of MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010year event\u2010free post\u2010MI patients were identified in the French claims database representative 1\/97 sample (2005\u20132010) and followed for up to 3\u00a0years. A PEGASUS\u2010like (PL) population included patients with age\u00a0\u2265\u00a065\u00a0years, or age\u00a0\u2265\u00a050 and diabetes, renal dysfunction or prior MI, without stroke, end\u2010stage renal failure or oral anticoagulation. Outcomes were: a composite of all\u2010cause death or hospital admission for MI or stroke; individual events; major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1585 post\u2010MI patients totalling 3926 person\u2013years including 865 PL patients (2114 PY); 68% were male; mean age was 66 (standard deviation 15) in post\u2010MI, 74 (10) in PL. Outcomes per 100 person\u2013years [95% confidence interval] were, respectively, in post\u2010MI and PL 6.3 [5.6\u20137.1] and 7.8 [6.7\u20138.9] for the composite outcome; 5.1 [4.4\u20135.8] and 6.5 [5.5\u20137.6] for death; 1.0 [0.7\u20131.3] and 1.0 [0.6\u20131.4] for MI; 0.6 [0.4\u20130.9] and 0.9 [0.5\u20131.2] for stroke; 1.3 [0.9\u20131.6] and 1.4 [0.9\u20131.9] for major bleeding. Event rates were stable over the 3 study years. Placebo patients in the PEGASUS\u2010TIMI54 Study were younger, more often male and had lower event rates, especially for all\u2010cause death and major bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients selected using the criteria described in PEGASUS were older with more comorbidities, resulting in higher all\u2010cause death and bleeding rates, but similar MI recurrence rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13291","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T04:58:23Z","timestamp":1490590703000},"page":"2056-2065","source":"Crossref","is-referenced-by-count":30,"title":["Outcomes in patients after myocardial infarction similar to those of the PEGASUS\u2010TIMI 54 trial: A cohort study in the French national claims database"],"prefix":"10.1111","volume":"83","author":[{"given":"Patrick","family":"Blin","sequence":"first","affiliation":[{"name":"Bordeaux PharmacoEpi, INSERM CIC1401 Universit\u00e9 de Bordeaux  33076 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dureau\u2010Pournin","sequence":"additional","affiliation":[{"name":"Bordeaux PharmacoEpi, INSERM CIC1401 Universit\u00e9 de Bordeaux  33076 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Lassalle","sequence":"additional","affiliation":[{"name":"Bordeaux PharmacoEpi, INSERM CIC1401 Universit\u00e9 de Bordeaux  33076 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Jov\u00e9","sequence":"additional","affiliation":[{"name":"Bordeaux PharmacoEpi, INSERM CIC1401 Universit\u00e9 de Bordeaux  33076 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Thomas\u2010Delecourt","sequence":"additional","affiliation":[{"name":"AstraZeneca  92400 Courbevoie 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