{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:05:24Z","timestamp":1792191924520,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:00:00Z","timestamp":1497484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001718","name":"Netherlands Organization for International Cooperation in Higher Education","doi-asserted-by":"publisher","award":["NFP\u2010PhD.12\/ 402"],"award-info":[{"award-number":["NFP\u2010PhD.12\/ 402"]}],"id":[{"id":"10.13039\/501100001718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001718","name":"Netherlands Organization for International Cooperation in Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the present study was to evaluate the impact of adverse drug events (ADEs) and treatment satisfaction on antihypertensive medication adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was conducted in six public hospitals in Ethiopia. We included adult ambulatory patients on antihypertensive medication. Adherence was measured using the eight\u2010point Morisky Medication Adherence Scale, which categorizes as low (0\u20135), medium (6\u20137) and high (8) adherence. Treatment satisfaction was measured using the Treatment Satisfaction Questionnaire for Medication (TSQM) version 1.4, which included questions about ADEs. Data were analysed using generalized ordered logistic regression with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 925 out of 968 patients. Overall, 42% of patients scored low, 37% medium and 21% high adherence. Satisfaction with treatment was low, with a mean (standard deviation) TSQM score for global satisfaction of 51 (14). A total of 193 (21%) patients experienced 421 ADEs \u2013 mainly dyspeptic symptoms (12%), headache (11%) and cough (11). Experiencing more ADEs reduced the odds of being adherent [low <jats:italic>vs.<\/jats:italic> medium\/high: odds ratio (OR) OR<jats:sub>1<\/jats:sub> 0.77 (95% CI 0.67, 0.89), and low\/medium <jats:italic>vs.<\/jats:italic> high: OR<jats:sub>2<\/jats:sub> 0.55 (05% CI 0.41, 0.73)]. Being more satisfied increased the odds of being adherent [low <jats:italic>vs.<\/jats:italic> medium\/high: OR<jats:sub>1<\/jats:sub> 1.02 (95% CI 1.01, 1.03)]. Taking medication &gt;1\u00a0year [OR<jats:sub>1\u00a0=\u00a02<\/jats:sub>, 0.60 (95% CI 0.43, 0.83)] and taking calcium channel blockers [OR<jats:sub>1\u00a0=\u00a02<\/jats:sub> 0.71 (95% CI 0.54, 0.92)] decreased the odds for both low <jats:italic>vs.<\/jats:italic> medium\/high and low\/medium <jats:italic>vs.<\/jats:italic> high adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only one in five patients reported perfect (high) adherence to their antihypertensive treatment regimen. Experiencing ADEs and being dissatisfied with treatment were associated with lower adherence. In addition to addressing treatment satisfaction and drug safety in first\u2010world countries, these should also be addressed in resource\u2010poor settings, within patient consultations, to enhance adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13312","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T06:55:12Z","timestamp":1492757712000},"page":"2107-2117","source":"Crossref","is-referenced-by-count":35,"title":["Impact of adverse drug events and treatment satisfaction on patient adherence with antihypertensive medication \u2013 a study in ambulatory patients"],"prefix":"10.1111","volume":"83","author":[{"given":"Derbew Fikadu","family":"Berhe","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, University of Groningen University Medical Center Groningen  The Netherlands"},{"name":"Department of Pharmacy, College of Health Sciences Mekelle University  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Taxis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Unit Pharmacotherapy, \u2010epidemiology and \u2010economics University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora M.","family":"Haaijer\u2010Ruskamp","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacology, University of Groningen University Medical Center Groningen  The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afework","family":"Mulugeta","sequence":"additional","affiliation":[{"name":"School of Public Health, College of Health Sciences Mekelle University  Mekelle Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yewondwossen Tadesse","family":"Mengistu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G. 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