{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:27:32Z","timestamp":1783643252208,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T00:00:00Z","timestamp":1498521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u2018Sapienza\u2019 University of Rome 2013 Research Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The pilot study was designed to evaluate the early effect of intravenous (i.v.) zoledronic acid (ZA) on renal function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five mg i.v. ZA was administered to 23 patients with osteoporosis (17 women and 6 men, mean age 73 \u00b1 7 SD years). Urinary NGAL, KIM\u20101, and MCP\u20101, plasma (p) MCP\u20101 and serum (s) IL\u201018, serum calcium (sCa), Creatinine clearance (CrCl), parathyroid hormone (PTH), plasma C\u2010terminal FGF23 (pFGF23), serum (s) Klotho, calcium excretion (CaEx) and renal threshold phosphate concentration\/GFR (TmPO<jats:sub>4<\/jats:sub>\/GFR) were assessed at baseline, 24\u00a0h and Day 30 after administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant decrease in sCa and CaEx at 24\u00a0h (\u22124.1 \u00b1 2.8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and \u221228 \u00b1 59%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, respectively) and Day 30 (\u22123.9 \u00b1 4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 and \u221226 \u00b1 43%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and a significant increase in PTH (79.8 \u00b1 95.8%) at Day 30 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared to baseline. TmPO<jats:sub>4<\/jats:sub>\/GFR decreased significantly at 24\u00a0h and Day 30 (\u22128.6 \u00b1 15.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 and \u221211.3 \u00b1 13.5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) compared to baseline. We observed no difference in the concentration of pFGF23, sKlotho and urinary AKI biomarkers at any time points. Mean levels of sIL\u201018 and pMCP\u20101 increased significantly at 24\u00a0h (44 \u00b1 88%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01 and 198 \u00b1 237%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and returned to baseline at Day 30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our pilot study suggests that there is no direct acute effect of ZA on kidney function. The increase in plasma MCP\u20101 and serum IL\u201018 concentration could be associated with the stimulation of immunity mechanisms occurring soon after the administration of the drug. Secondary hyperparathyroidism develops shortly after the infusion of ZA and is maintained even after 1 month.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13332","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:22:44Z","timestamp":1495732964000},"page":"2266-2273","source":"Crossref","is-referenced-by-count":17,"title":["Effect of a single intravenous zoledronic acid administration on biomarkers of acute kidney injury (AKI) in patients with osteoporosis: a pilot study"],"prefix":"10.1111","volume":"83","author":[{"given":"Cristiana","family":"Cipriani","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Medical Disciplines \u2018Sapienza\u2019 University of Rome  Viale del Policlinico 155 00161 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Pepe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Medical Disciplines \u2018Sapienza\u2019 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