{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:20:53Z","timestamp":1740126053420,"version":"3.37.3"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Sudden cardiac arrest (SCA) is a complex multifactorial event and most commonly caused by ventricular tachycardia\/ fibrillation (VT\/ VF). Some antihypertensive drugs could induce hypokalaemia or hyperkalaemia, which may increase susceptibility to VT\/VF and SCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the association between different classes of antihypertensive drugs classified according to their potential impact on serum potassium levels and the occurrence of out\u2010of\u2010hospital cardiac arrest (OHCA) based on VT\/VF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control study was performed among current users of antihypertensive drugs. Cases were OHCA victims with electrocardiogram documented VT\/VF drawn from the AmsteRdam REsuscitation STudies (ARREST) registry, and controls were non\u2010OHCA individuals from the PHARMO database. Antihypertensive drugs were classified into: (i) antihypertensives with neutral effect on serum potassium levels; (ii) hypokalaemia\u2010inducing antihypertensives; (iii) hyperkalaemia\u2010inducing antihypertensives; (iv) combination of antihypertensives with hypo\u2010 and hyperkalaemic effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1345 cases and 4145 controls. The risk of OHCA was significantly increased among users of hypokalaemia\u2010inducing antihypertensives [adjusted odds ratio (OR) 1.39; 95% confidence interval (CI) 1.10\u20131.76] and among users of a combination of antihypertensives with hypo\u2010 and hyperkalaemic effects (adjusted OR 1.42; 95%CI 1.17\u20131.72) <jats:italic>vs.<\/jats:italic> users of antihypertensives with neutral effect. There was no difference in OHCA risk between users of hyperkalaemia\u2010inducing antihypertensives <jats:italic>vs.<\/jats:italic> users of antihypertensive drugs with neutral effect (adjusted OR 1.15; 95%CI 0.95\u20131.40).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of OHCA is significantly increased in patients who were current users of hypokalaemia\u2010inducing antihypertensives and patients using a combination of antihypertensives with hypo\u2010 and hyperkalaemic effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13356","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T22:46:45Z","timestamp":1498776405000},"page":"2541-2548","source":"Crossref","is-referenced-by-count":7,"title":["The impact of serum potassium\u2010influencing antihypertensive drugs on the risk of out\u2010of\u2010hospital cardiac arrest: A case\u2013control study"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-1962","authenticated-orcid":false,"given":"Fawaz F.","family":"Alharbi","sequence":"first","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick C.","family":"Souverein","sequence":"additional","affiliation":[{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark C. 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