{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:48:42Z","timestamp":1780534122629,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["113201004"],"award-info":[{"award-number":["113201004"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The palatability of a new paediatric formulation of valaciclovir was assessed in children and their parents: non\u2010inferiority of the new paediatric formulation (test formulation) compared to the reference formulation was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>In vivo<\/jats:italic> palatability testing was performed in a randomized, two\u2010period, multicentre, cross\u2010over study. Children and their parents scored the liking of the new paediatric valaciclovir formulation and the reference formulation on a 100\u00a0mm visual analogue scale (VAS). To support formulation development and palatability testing, electronic tongue measurements were applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The electronic tongue measurement indicated taste\u2010masking capabilities for three different formulations in the developmental phase. A glycerol\u2010based formulation was further tested and compared to the reference formulation prepared out of crushed and suspended tablets. The mean difference (95% CI) in VAS scores between both formulations, as indicated by the children (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), was 2.4 (\u22128.5, 13) mm, in favour of the new paediatric valaciclovir formulation. The mean (95% CI) difference in VAS scores indicated by the parents (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) was \u22120.9 (\u221212, 9.8) mm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The palatability of the new paediatric valaciclovir formulation was considered non\u2010inferior to the reference formulation prepared out of crushed tablets. We were able to optimize the study design and number of children to be included in the palatability testing by using electronic tongue measurements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13396","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T19:36:35Z","timestamp":1502480195000},"page":"2789-2797","source":"Crossref","is-referenced-by-count":11,"title":["<i>In vivo<\/i> and <i>in vitro<\/i> palatability testing of a new paediatric formulation of valaciclovir"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8680-6109","authenticated-orcid":false,"given":"Diane E. 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