{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T09:39:08Z","timestamp":1774345148422,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DBS20140930781"],"award-info":[{"award-number":["DBS20140930781"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Argon has been shown to prevent ischaemic injuries in several scenarios of regional ischaemia. We determined whether it could provide a systemic effect in a model of multiorgan failure (MOF) induced by aortic cross\u2010clamping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anaesthetized rabbits were submitted to aortic cross\u2010clamping (30\u00a0min) and subsequent reperfusion (300\u00a0min). They were either ventilated with oxygen\u2010enriched air throughout the protocol [fraction of inspired oxygen (FiO<jats:sub>2<\/jats:sub>) = 30%; control group) or with a mixture of 30% oxygen and 70% argon (argon groups). In a first group treated with argon (\u2018Argon\u2010Total\u2019), its administration was started 30\u00a0min before ischaemia and maintained throughout the protocol. In the two other groups, the administration was started either 30\u00a0min before ischaemia (\u2018Argon\u2010Pre\u2019) or at the onset of reperfusion (\u2018Argon\u2010Post\u2019), for a total duration of 2\u00a0h. Cardiovascular, renal and inflammatory endpoints were assessed throughout protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with control, shock was significantly attenuated in Argon\u2010Total and Argon\u2010Pre but not Argon\u2010Post groups (e.g. cardiac output = 62\u00b15 <jats:italic>vs.<\/jats:italic> 29\u00a0\u00b1\u00a05\u00a0ml min<jats:sup>\u22121<\/jats:sup> kg<jats:sup>\u22121<\/jats:sup> in Argon\u2010Total and control groups at the end of the follow\u2010up). Shock and renal failure were reduced in all argon <jats:italic>vs.<\/jats:italic> control groups. Histopathological examination of the gut showed attenuation of ischaemic lesions in all argon <jats:italic>vs.<\/jats:italic> control groups. Blood transcription levels of interleukin (IL) 1\u03b2, IL\u20108, IL\u201010 and hypoxia\u2010inducible factor 1\u03b1 were not significantly different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Argon attenuated clinical and biological modifications of cardiovascular, renal and intestinal systems, but not the inflammatory response, after aortic cross\u2010clamping. The window of administration was crucial to optimize organ protection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13535","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T03:26:39Z","timestamp":1517455599000},"page":"1170-1179","source":"Crossref","is-referenced-by-count":6,"title":["Argon attenuates multiorgan failure following experimental aortic cross\u2010clamping"],"prefix":"10.1111","volume":"84","author":[{"given":"Guillaume","family":"Savary","sequence":"first","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est, UMR_S955, UPEC, DHU A\u2010TVB Cr\u00e9teil  France"},{"name":"Universit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Lidouren","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Rambaud","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est, UMR_S955, UPEC, DHU A\u2010TVB Cr\u00e9teil  France"},{"name":"Universit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Kohlhauer","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est, UMR_S955, UPEC, DHU A\u2010TVB Cr\u00e9teil  France"},{"name":"Universit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Hauet","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine et de Pharmacie Inserm, U1082, Universit\u00e9 de Poitiers  Poitiers France"},{"name":"Service de Biochimie CHU de Poitiers  Poitiers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[{"name":"Service d'Anatomie Pathologique H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Costes","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 5  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Cariou","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation M\u00e9dicale H\u00f4pitaux Universitaires Paris Centre, H\u00f4pital Cochin, Assistance Publique des H\u00f4pitaux de Paris  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Ghaleh","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est, UMR_S955, UPEC, DHU A\u2010TVB Cr\u00e9teil  France"},{"name":"Universit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Mongardon","sequence":"additional","affiliation":[{"name":"Inserm, U955, Equipe 3  Cr\u00e9teil France"},{"name":"Universit\u00e9 Paris Est, UMR_S955, UPEC, DHU A\u2010TVB Cr\u00e9teil  France"},{"name":"Universit\u00e9 Paris Est, Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort  Maisons\u2010Alfort France"},{"name":"Service d'Anesth\u00e9sie et des R\u00e9animations Chirurgicales, DHU A\u2010TVB H\u00f4pitaux Universitaires Henri Mondor, Assistance Publique des H\u00f4pitaux de Paris  Cr\u00e9teil 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