{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:08:16Z","timestamp":1782212896521,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shibaiqian talents program","award":["Wuhan Government in the year of 2015"],"award-info":[{"award-number":["Wuhan Government in the year of 2015"]}]},{"DOI":"10.13039\/501100010849","name":"Health and Family Planning Commission of Wuhan municipality","doi-asserted-by":"crossref","award":["WX16B12"],"award-info":[{"award-number":["WX16B12"]}],"id":[{"id":"10.13039\/501100010849","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Yellow crane talents program","award":["Wuhan Government in the year of 2015"],"award-info":[{"award-number":["Wuhan Government in the year of 2015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The full benefits of myocardial revascularization strategies applied to acute myocardial infarction patients might be reduced by myocardial ischaemia and reperfusion (I\/R) injury. It is known that inflammation plays an important role in the pathogenesis of I\/R injury and galectin\u20103, a known inflammatory factor, is actively involved in ischaemia\u2010induced inflammation and fibrosis of various organs. Previous studies demonstrated that anti\u2010platelets therapy with ticagrelor, a new P2Y12 receptor antagonist, could effectively attenuate myocardial I\/R injury and I\/R injury\u2010related inflammatory responses. It remains unknown whether the cardioprotective effects of ticagrelor are also mediated by modulating myocardial galectin\u20103 expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We determined the ratio of infarct area (IA)\/area at risk (AAR), expression of galectin\u20103, TNF\u2010\u03b1 and IL\u20106 in infarct area of rats treated with placebo (equal volume saline per gastric gavage immediately after LAD ligation, then once daily till study end) or ticagrelor (150\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> dissolved in saline per gastric gavage immediately after LAD ligation, then once daily till study end) at 24\u00a0h, 3 and 7 days post I (45\u00a0min)\/R injury. Sham\u2010operated rats served as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that ticagrelor treatment significantly reduced IA\/AAR ratio at 3 and 7 days post I\/R, downregulated mRNA and protein expression of galectin\u20103, as well as mRNA expression of TNF\u2010\u03b1 and IL\u20106 in infarct area at 24\u00a0h, 3 and 7 days post I\/R.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the cardioprotective effects of ticagrelor might partly be mediated by downregulating galectin\u20103 expression in infarct area in this rat model of myocardial I\/R injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13536","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T20:52:39Z","timestamp":1517345559000},"page":"1180-1186","source":"Crossref","is-referenced-by-count":25,"title":["Ticagrelor attenuates myocardial ischaemia\u2013reperfusion injury possibly through downregulating galectin\u20103 expression in the infarct area of rats"],"prefix":"10.1111","volume":"84","author":[{"given":"Xiaogang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-1488","authenticated-orcid":false,"given":"Liqun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Puai Hospital, Huazhong University of Science and Technology  430033 Wuhan 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