{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:14Z","timestamp":1740126074067,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Adverse Event<\/jats:title><jats:p>Warfarin\u2010related nephropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Drug Implicated<\/jats:title><jats:p>Warfarin.<\/jats:p><\/jats:sec><jats:sec><jats:title>The Patient<\/jats:title><jats:p>A 31\u2010year\u2010old female, managed with warfarin for rheumatic heart disease with atrial fibrillation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Evidence that Links the Drug to the Event<\/jats:title><jats:p>There were no alternative causes of nephropathy that could have caused the adverse event in this patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Management<\/jats:title><jats:p>Shifting the drug from warfarin to acenocoumarol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Mechanism<\/jats:title><jats:p>Difference in renal elimination between warfarin and acenocoumarol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implication for Therapy<\/jats:title><jats:p>Clinicians should be aware of this rare adverse effect of warfarin, and acenocoumarol can be considered as an alternative therapy for this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypotheses to be Tested<\/jats:title><jats:p>Further prospectively designed studies are needed to consider acenocoumarol as an alternative therapy in warfarin\u2010related nephropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13541","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T01:16:48Z","timestamp":1518139008000},"page":"1068-1071","source":"Crossref","is-referenced-by-count":5,"title":["Acenocoumarol as an alternative anticoagulant in a patient with warfarin\u2010related nephropathy"],"prefix":"10.1111","volume":"84","author":[{"given":"Sapan Kumar","family":"Behera","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-7862","authenticated-orcid":false,"given":"Alphienes Stanley","family":"Xavier","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-7821","authenticated-orcid":false,"given":"Sandhiya","family":"Selvarajan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemachandren","family":"Munuswamy","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic &amp; Vascular Surgery Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Haridasan","sequence":"additional","affiliation":[{"name":"Department of Nephrology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bheemanathi Hanuman","family":"Srinivas","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"e_1_2_3_2_1","unstructured":"FDA.www.accessdata.fda.gov.2017.www.accessdata.fda.gov\/drugsatfda_docs\/anda\/99\/40301_warfarin%20sodium_prntlbl.pdf(last accessed 30 August 2017)."},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13229"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2014.11.001"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.024"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057661"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-4065.177142"},{"key":"e_1_2_3_8_1","first-page":"88","article-title":"Acenocoumarol: a review of anticoagulant efficacy and safety","volume":"64","author":"Trailokya A","year":"2016","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_3_9_1","first-page":"1","article-title":"Warfarin related nephropathy: a case report and review of the literature","volume":"17","author":"Ng CY","year":"2016","journal-title":"BMC Nephrol"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:06:45Z","timestamp":1695546405000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,28]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/bcp.13541"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13541","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"type":"print","value":"0306-5251"},{"type":"electronic","value":"1365-2125"}],"subject":[],"published":{"date-parts":[[2018,2,28]]}}}