{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:38:37Z","timestamp":1774607917489,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Preventing post\u2010liver transplantation (LT) hepatic artery and portal vein thrombosis includes enoxaparin administration. Enoxaparin pharmacokinetics (PK) has not been investigated in children following LT. We described an enoxaparin PK model in 22 children the first week following LT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Anti\u2010Xa activity time\u2010courses were analysed using a nonlinear mixed effects approach with Monolix version 2016R.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anti\u2010Xa activity time\u2010courses were well described by a one\u2010compartment model with first order absorption and elimination. Bodyweight prior to surgery (BW<jats:sub>PREOP<\/jats:sub>) and the related postoperative variation (BW(t)) were the main covariates explaining CL and V between subject variabilities. Parameter estimates were CL<jats:sub>i<\/jats:sub>\u00a0=\u00a0CL<jats:sub>TYP<\/jats:sub> * (BW<jats:sub>PREOP<\/jats:sub>\/70)<jats:sup>3\/4<\/jats:sup>; V<jats:sub>i<\/jats:sub>\u00a0=\u00a0V<jats:sub>TYP<\/jats:sub> * (BW(t)\/70)<jats:sup>1<\/jats:sup>; where typical clearance (CL<jats:sub>TYP<\/jats:sub>) and typical volume of distribution (V<jats:sub>TYP<\/jats:sub>) were 1.23\u00a0l\u00a0h<jats:sup>\u22121<\/jats:sup> and 14.6\u00a0l, respectively. Standard dosing regimens of 50\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a012\u00a0h<jats:sup>\u22121<\/jats:sup> were insufficient to reach the target range of anti\u2010Xa activity of 0.2\u20130.4\u00a0IU\u00a0ml<jats:sup>\u22121<\/jats:sup>. Specifically, seven children (32%) never attained the target range during the whole period of treatment and all children were at least once underdosed. According to the final results, we simulated individualized dosing regimens within 4\u00a0h following the first administration. More than 100\u00a0IU\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a012\u00a0h<jats:sup>\u22121<\/jats:sup> are suggested to reach the target range of anti\u2010Xa activity of 0.2\u20130.4\u00a0IU\u00a0ml<jats:sup>\u22121<\/jats:sup> from the first day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thanks to this model, the initial and maintenance doses could be assessed to rapidly achieve the target range. Higher doses per kg, especially in the youngest children, are suggested.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13543","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T02:06:40Z","timestamp":1518142000000},"page":"1206-1214","source":"Crossref","is-referenced-by-count":2,"title":["Population pharmacokinetics of enoxaparin in early stage of paediatric liver transplantation"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-5948","authenticated-orcid":false,"given":"Mehdi","family":"Oualha","sequence":"first","affiliation":[{"name":"Service de r\u00e9animation et surveillance continue m\u00e9dico\u2010chirurgicales, H\u00f4pital Necker Enfants\u2010Malades Universit\u00e9 Paris Descartes  Sorbonne\u2010Paris Cit\u00e9, 149 rue de S\u00e8vres 75015 Paris France"},{"name":"EA7323, Evaluation des th\u00e9rapeutiques et pharmacologie p\u00e9rinatale et p\u00e9diatrique Universit\u00e9 Paris Descartes  Paris 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Sorbonne\u2010Paris Cit\u00e9, 149 rue de S\u00e8vres 75015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Harroche","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie clinique, H\u00f4pital Necker Enfants\u2010Malades Universit\u00e9 Paris Descartes  Sorbonne\u2010Paris Cit\u00e9, 149 rue de S\u00e8vres 75015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Renolleau","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation et surveillance continue m\u00e9dico\u2010chirurgicales, H\u00f4pital Necker Enfants\u2010Malades Universit\u00e9 Paris Descartes  Sorbonne\u2010Paris Cit\u00e9, 149 rue de S\u00e8vres 75015 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Treluyer","sequence":"additional","affiliation":[{"name":"Service de r\u00e9animation et surveillance continue 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