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Splitting them into distinct age groups (18\u201324, 25\u201349 and \u226550\u00a0years of age for adults and &lt;6, 6\u201311 and 12\u201317 years of age for children), we established the characteristics of these populations at MPH initiation and during follow\u2010up according to the duration of treatment, quantities dispensed and coprescription with central nervous system (CNS) drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included a cohort of 3534 incident users, involving 30\u2009238 dispensings of MPH, leading to an annual rate of 29 incident users per 100\u2009000 in 2013. Children (66% of new users) were characterized by long\u2010term use of MPH with few comedications. The group of 25\u201349\u2010year\u2010old patients were dispensed MPH more frequently than other groups, had the highest mean dose and were more often coprescribed other CNS drugs. The \u226550\u00a0year\u2010old group was more often coprescribed antidepressants and antiparkinsonian drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our pharmacoepidemiological study involving incident MPH users with a large number of characteristics showed different patterns of MPH use among children and adults. The results from the 25\u201349\u2010year\u2010old group suggested that MPH might be being used for medical conditions other than ADHD or narcolepsy in adults, and that it might be subject to misuse and\/or abuse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13544","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T06:35:50Z","timestamp":1520404550000},"page":"1215-1227","source":"Crossref","is-referenced-by-count":34,"title":["Patterns and profiles of methylphenidate use both in children and adults"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-1781","authenticated-orcid":false,"given":"Vanessa","family":"Pauly","sequence":"first","affiliation":[{"name":"Laboratoire de sant\u00e9 publique EA 3279, Centre d'\u00e9valuation de la pharmacod\u00e9pendance\u2010addictovigilance (CEIP\u2010A) de Marseille (PACA Corse) associ\u00e9, Facult\u00e9 de m\u00e9decine Aix\u2010Marseille Universit\u00e9  13005 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1879-5625","authenticated-orcid":false,"given":"Elisabeth","family":"Frauger","sequence":"additional","affiliation":[{"name":"Service de pharmacologie clinique et pharmacovigilance, CNRS, CEIP \u2010 addictovigilance PACA Corse, INSERM 1106, Institut des neurosciences des systemes, CHU Timone, Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille universit\u00e9  13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magalie","family":"Lepelley","sequence":"additional","affiliation":[{"name":"Centre d'Addictovigilance (CEIP) de Grenoble Pavillon E CHU  38043 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Mallaret","sequence":"additional","affiliation":[{"name":"Centre d'Addictovigilance (CEIP) de Grenoble Pavillon E CHU  38043 Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Boucherie","sequence":"additional","affiliation":[{"name":"Service de pharmacologie clinique et pharmacovigilance, CNRS, CEIP \u2010 addictovigilance PACA Corse, INSERM 1106, Institut des neurosciences des systemes, CHU Timone, Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille universit\u00e9  13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-7835","authenticated-orcid":false,"given":"Jo\u00eblle","family":"Micallef","sequence":"additional","affiliation":[{"name":"Service de pharmacologie clinique et pharmacovigilance, CNRS, CEIP \u2010 addictovigilance PACA Corse, INSERM 1106, Institut des neurosciences des systemes, CHU Timone, Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille universit\u00e9  13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439273"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2015012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2013.09.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867414538675"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13000"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03373.x"},{"key":"e_1_2_9_8_1","unstructured":"ANSM.Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9. 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