{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:19:18Z","timestamp":1761974358588,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Nalmefene, an opioid antagonist, has recently been approved for the treatment of alcohol dependence. We describe here the first case of a 52\u2010year\u2010old woman who developed a severe central sleep apnoea (CSA) 5\u00a0months after initiation of nalmefene. Scoring of ventilation during sleep recording revealed an apnoea\u2010hypopnoea index of 67\/h with 98.7% of central events and an apnoea index of 65\/h. Nalmefene was withdrawn and a new polysomnography was performed which concluded that CSA has disappeared. Pathophysiology is still unclear but could involve the \u03ba\u2010opioid receptors. Physicians should be aware that CSA might affect patients treated with nalmefene. Further investigations are required to determine the pathophysiology, frequency, and treatment of CSA associated with nalmefene and other therapy for alcohol disorders.<\/jats:p>","DOI":"10.1111\/bcp.13547","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:11:56Z","timestamp":1519625516000},"page":"1075-1076","source":"Crossref","is-referenced-by-count":4,"title":["Severe central sleep apnoea associated with nalmefene: a case report"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-8573","authenticated-orcid":false,"given":"Charles","family":"Khouri","sequence":"first","affiliation":[{"name":"Pharmacovigilance Unit Grenoble Alps University Hospital  Grenoble France"},{"name":"Clinical Pharmacology Department, INSERM CIC1406 Grenoble Alps University Hospital  Grenoble France"},{"name":"HP2 Laboratory, INSERM U1042 Grenoble Alps University  Grenoble 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