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Topical drugs were applied pre\u2010 and\/or post\u2010treatment in block designs. The compounds were tested simultaneously under occluded patch tests covering DPCP\u2010induced dermatitis. Inhibitory responses were assessed by visual scoring and measurements of the oedema thickness with ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When applied both before and after the DPCP challenge, significant anti\u2010inflammatory effects were seen in descending order for tacrolimus 0.1% ointment, clobetasol propionate ointment, betamethasone valerate ointment and hydrocortisone butyrate ointment, while pimecrolimus cream, hydrocortisone ointment and vehicles had no significant effect. Only tacrolimus ointment (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) demonstrated a consistent significant pre\u2010treatment inhibitory effect compared with an untreated DPCP control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This human testing method in which the inflammation of experimentally induced allergic patch test reactions is quantified by objective measurement allows an analysis of the anti\u2010inflammatory potency of not only topical corticosteroids, but also of drugs that have no effect on vasoconstriction. The method allowed comparison of the potencies of four topical corticosteroids and two calcineurin inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13596","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T05:21:32Z","timestamp":1522646492000},"page":"1719-1728","source":"Crossref","is-referenced-by-count":18,"title":["Anti\u2010inflammatory potency testing of topical corticosteroids and calcineurin inhibitors in human volunteers sensitized to diphenylcyclopropenone"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3689-7350","authenticated-orcid":false,"given":"Kristian F.","family":"Mose","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre, Odense University Hospital University of Southern Denmark  5000 Odense C Denmark"},{"name":"Dermatological Investigations Scandinavia  J.B. 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