{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:09:28Z","timestamp":1790525368002,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Agence R\u00e9gionale de Sant\u00e9 de Midi-Pyr\u00e9n\u00e9es"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Potentially inappropriate drug prescribing (PIDP) is frequent in nursing home (NH) residents. We aimed to investigate whether a geriatric intervention on quality of care reduced PIDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed an ancillary study within a multicentric individually\u2010tailored controlled trial (IQUARE trial). All NH received a baseline and 18\u2010month audit regarding drug prescriptions and other quality of care indicators. After the initial audit, NHs of the intervention group benefited of an in\u2010site intervention (geriatric education for NH staff) provided by a geriatrician from the closest hospital. The analysis included 629 residents of 159 NHs. The main outcome was PIDP, defined as the presence of at least one of the following criteria: (i) drug with an unfavourable benefit\u2010to\u2010risk ratio; (ii) with questionable efficacy; (iii) absolute contraindication; (iv) significant drug\u2010drug interaction. Multivariable multilevel logistic regression models were performed including residents and NH factors as confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PIDP was 65.2% (\u20133.6% from baseline) in the intervention group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0339) and 69.9% (\u20132.3%) in the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0290). The intervention significantly decreased PIDP [odds ratio (OR)\u00a0=\u00a00.63; 95% confidence interval 0.40\u20130.99], as a special care unit in NH (OR\u00a0=\u00a00.60; (0.42 to 0.85)), and a fall in the last 12\u00a0months (OR\u00a0=\u00a00.63; 0.44\u20130.90). Charlson Comorbidity Index [OR<jats:sub>CCI\u00a0=\u00a01 <jats:italic>vs<\/jats:italic>. 0<\/jats:sub>\u00a0=\u00a01.38; 0.87\u20132.19, OR<jats:sub>CCI\u00a0\u2265\u00a02 <jats:italic>vs<\/jats:italic>. 0<\/jats:sub>\u00a0=\u00a02.01; (1.31\u20133.08)] and psychiatric advice and\/or hospitalization in a psychiatric unit (OR\u00a0=\u00a01.53; 1.07\u20132.18) increased the likelihood of PIDP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This intervention based on a global geriatric education resulted in a significant reduction of PIDP at patient level.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13598","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T06:12:38Z","timestamp":1522649558000},"page":"1598-1610","source":"Crossref","is-referenced-by-count":15,"title":["Reducing potentially inappropriate drug prescribing in nursing home residents: effectiveness of a geriatric intervention"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-1568","authenticated-orcid":false,"given":"Charl\u00e8ne","family":"Cool","sequence":"first","affiliation":[{"name":"UMR INSERM 1027 University of Toulouse III  Toulouse France"},{"name":"P\u00f4le Pharmacie, Centre Hospitalo\u2010Universitaire (CHU) de Toulouse  1 avenue Jean Poulh\u00e8s F 31059 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Cestac","sequence":"additional","affiliation":[{"name":"UMR INSERM 1027 University of Toulouse III  Toulouse France"},{"name":"P\u00f4le Pharmacie, Centre Hospitalo\u2010Universitaire (CHU) de Toulouse  1 avenue Jean Poulh\u00e8s F 31059 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"McCambridge","sequence":"additional","affiliation":[{"name":"P\u00f4le Pharmacie, Centre Hospitalo\u2010Universitaire (CHU) de Toulouse  1 avenue Jean Poulh\u00e8s F 31059 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Rouch","sequence":"additional","affiliation":[{"name":"UMR INSERM 1027 University of Toulouse III  Toulouse France"},{"name":"P\u00f4le Pharmacie, Centre Hospitalo\u2010Universitaire (CHU) de Toulouse  1 avenue Jean Poulh\u00e8s F 31059 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8860-425X","authenticated-orcid":false,"given":"Philipe","family":"de Souto Barreto","sequence":"additional","affiliation":[{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"},{"name":"UMR 7268 Aix\u2010Marseille, Laboratoire d'Anthropologie bioculturelle, droit, \u00e9thique et sant\u00e9  France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Rolland","sequence":"additional","affiliation":[{"name":"UMR INSERM 1027 University of Toulouse III  Toulouse France"},{"name":"G\u00e9rontop\u00f4le de Toulouse, Institut du Vieillissement Centre Hospitalo\u2010Universitaire de Toulouse  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5494-5873","authenticated-orcid":false,"given":"Maryse","family":"Lapeyre\u2010Mestre","sequence":"additional","affiliation":[{"name":"UMR INSERM 1027 University of Toulouse III  Toulouse France"},{"name":"Service de Pharmacologie M\u00e9dicale et Clinique, CIC Inserm 1436 CHU de Toulouse  37 All\u00e9es Jules Guesde F 31000 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61460-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2006.09.011"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0197-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr233"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03909.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-013-0008-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0422-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03628.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.08.003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs.2009.039818"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/02813431003765455"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1Q597"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-016-2193-z"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-11-79"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K154"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00451-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.02961.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1249-y"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630990-000000000-00000"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12059"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1575-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12284"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.09.003"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1E230"},{"key":"e_1_2_10_26_1","first-page":"1","article-title":"Potentially preventable emergency department visits by nursing home residents: United States, 2004","author":"Caffrey C","year":"2010","journal-title":"NCHS Data Brief"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02932.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjopharm.2010.05.004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq161"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2165\/0002512-200926010-00003"},{"key":"e_1_2_10_31_1","first-page":"CD009095","article-title":"Interventions to optimise prescribing for older people in care homes","volume":"2","author":"Alldred DP","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-11-16"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.09.002"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.07.017"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2012.10.018"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.01.092"},{"key":"e_1_2_10_37_1","unstructured":"World Health Organization Collaborating Centre for Drug Statistics Methodology.Guidelines for ATC classification and DDD assignment. Available athttp:\/\/www.whocc.no\/atc_ddd_index\/(last accessed 29 January 2018)"},{"key":"e_1_2_10_38_1","unstructured":"Minist\u00e8re des affaires sociales et de la sant\u00e9.Base de donn\u00e9es publique des m\u00e9dicaments. Available athttp:\/\/base\u2010donnees\u2010publique.medicaments.gouv.fr\/ (last accessed 29 January 2018)"},{"key":"e_1_2_10_39_1","unstructured":"Agence Nationale de S\u00e9curit\u00e9 du M\u00e9dicament et des produits de sant\u00e9 (ANSM).ANSM\u00a0: Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9. Available athttp:\/\/ansm.sante.fr\/ (last accessed 29 January 2018)"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-007-0324-2"},{"key":"e_1_2_10_41_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 (HAS).Recommandations de bonnes pratique clinique chez les personnes \u00e2g\u00e9es. Available athttp:\/\/www.has\u2010sante.fr\/portail\/jcms\/c_39085\/fr\/recherche?portlet=c_39085&text=personnes+%C3%A2g%C3%A9es&opSearch=&lang=fr&FACET_TYPE=guidelines(last accessed 29 December 2017)"},{"key":"e_1_2_10_42_1","unstructured":"HoxJ.Applied multilevel analysis.1995."},{"key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/0471722146","volume-title":"applied logistic regression","author":"Hosmer D","year":"2000"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19970515)16:9<965::AID-SIM509>3.0.CO;2-O"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13882"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12847"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12959"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aprim.2015.07.004"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cali.2015.09.008"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13122"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.71"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2008.01080.x"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0982-3"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2011.01682.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-016-0406-2"},{"key":"e_1_2_10_57_1","first-page":"CD000336","article-title":"Effect of outpatient pharmacists' non\u2010dispensing roles on patient outcomes and prescribing patterns","author":"Nkansah N","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50004.x"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13598","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:05:50Z","timestamp":1694667950000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/bcp.13598"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13598","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]}}}