{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:59:39Z","timestamp":1780412379393,"version":"3.54.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104\u20102320\u2010B\u2010006\u2010008\u2010MY3"],"award-info":[{"award-number":["MOST 104\u20102320\u2010B\u2010006\u2010008\u2010MY3"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104\u20102314\u2010B\u2010006\u2010020\u2010MY2"],"award-info":[{"award-number":["MOST 104\u20102314\u2010B\u2010006\u2010020\u2010MY2"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to investigate the putative link between dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i) use and the risk of fracture in patients with type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This propensity\u2010score\u2010matched population\u2010based cohort study was performed between 2009 and 2013 on patients with type 2 diabetes who were stable metformin users. A total of 3996 patients with type 2 diabetes used DPP\u20104i as a second\u2010line antidiabetic drug. The same number of matched non\u2010DPP\u20104i users were followed up until fracture occurrence, health insurance policy termination, or the end of 2013. The incidence rates of overall and cause\u2010specific fractures were estimated based on the Poisson assumption. A multiple Cox proportional hazard model was used to estimate the covariate\u2010adjusted hazard ratio (HR) and 95% confidence interval (CI) to determine the association between DPP\u20104i use and overall and cause\u2010specific fractures stratified by age and sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a maximum follow\u2010up period of 5 years, 340 DPP\u20104i users and 419 non\u2010DPP\u20104i users were newly diagnosed with fractures, yielding incidence rates of 28.03 and 32.04 per 1000 people per year, respectively. The Cox proportional hazard model revealed that DPP\u20104i use significantly reduced the risk of all\u2010cause fractures and upper extremity fractures, with adjusted HRs of 0.86 (95% CI: 0.74\u20130.99) and 0.75 (95% CI: 0.59\u20130.95), respectively. The aforementioned associations of DDP\u20104i use with fracture were sustained across sex and age stratifications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study supported the premise that DPP\u20104i usage is associated with a reduced risk of all\u2010cause fractures and upper extremity fractures in patients with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13636","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T08:09:32Z","timestamp":1526458172000},"page":"2029-2039","source":"Crossref","is-referenced-by-count":34,"title":["Dipeptidyl peptidase\u20104 inhibitor use is associated with decreased risk of fracture in patients with type 2 diabetes: a population\u2010based cohort 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