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They first appeared on her abdomen and gradually spread to her lower back, thighs, before spreading to her upper and lower limbs. Her lesions were non\u2010painful, aggravated by sun exposure only, and sparing mucous membranes. Nikolsky sign was positive with no discernible fluid\u2010filled bullae. History was remarkable only for a doubling of her Lisinopril dosage 2\u00a0months prior to the appearance of her lesions, with no other potential environmental and\/or drug triggers recognizable on history taking. In light of the appearance of her lesions after her Lisinopril dose escalation, in the absence of any other discernible triggers, an adverse drug reaction (ADR) was entertained, yielding a corresponding Naranjo ADR probability score of 7. Particularly, drug\u2010induced pemphigus foliaceus was initially suspected given her clinical presentation and the morphology and distribution of her lesions. However, her skin biopsy altered our diagnosis to drug\u2010induced bullous pemphigoid (BP) instead, making this the second case reported to date on Lisinopril\u2010induced BP, and the first to report a dose\u2013response variant of this adverse reaction.<\/jats:p>","DOI":"10.1111\/bcp.13737","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T06:40:02Z","timestamp":1535611202000},"page":"2678-2682","source":"Crossref","is-referenced-by-count":13,"title":["Lisinopril\u2010associated bullous pemphigoid in an elderly woman: a case report of a rare adverse drug reaction"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-0895","authenticated-orcid":false,"given":"Rami A.","family":"Ballout","sequence":"first","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umayya","family":"Musharrafieh","sequence":"additional","affiliation":[{"name":"Department of Family Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Khattar","sequence":"additional","affiliation":[{"name":"Department of Family Medicine American University of Beirut Medical Center  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0264-2"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a180"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.006"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.01.016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12366"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002808902300115"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70262-R"},{"key":"e_1_2_6_9_1","first-page":"100","article-title":"Bullous pemphigoid associated with captopril","volume":"30","author":"Zaballos P","year":"2002","journal-title":"Med Cutan Ibero Lat Am"},{"key":"e_1_2_6_10_1","first-page":"181","article-title":"Ramipril\u2010induced bullous drug eruptions","volume":"14","author":"Agrawal SS P","year":"2013","journal-title":"J Indian Acad Clin Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07453.x"},{"key":"e_1_2_6_12_1","first-page":"153","article-title":"Lisinopril\u2010induced pemphigus foliaceus in a patient with diabetes mellitus and Kaposi\u2010Juliusberg varicelliform eruption","volume":"4","author":"Dobrosavljevi\u0107 Vukojevi\u0107 D","year":"2012","journal-title":"Serb J Derm Venereol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630310013379"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.03.012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1679-45082017rc3828"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03839.x"},{"key":"e_1_2_6_18_1","first-page":"187","article-title":"Mucocutaneous bullous pemphigoid induced by valsartan. 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