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Although the HIPEC procedure is adopted throughout the world, major differences exist between treatment protocols regarding the carrier solution, perfusate volume, use of an open or closed technique, duration of the perfusion and application of additional flushing. These differences can influence the pharmacokinetics and pharmacodynamics of oxaliplatin and might thereby have an impact on the efficacy and\/or safety of the treatment. Clinicians should be aware of the clinical importance of oxaliplatin pharmacology when performing HIPEC surgery. This review adds new insights into the complex field of the pharmacology of HIPEC and highlights an important worldwide problem: the lack of standardization of the HIPEC procedure.<\/jats:p>","DOI":"10.1111\/bcp.13773","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T01:04:08Z","timestamp":1537923848000},"page":"47-58","source":"Crossref","is-referenced-by-count":27,"title":["Hyperthermic intraperitoneal chemotherapy with oxaliplatin for peritoneal carcinomatosis: a clinical pharmacological perspective on a surgical procedure"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-8386","authenticated-orcid":false,"given":"Loek A. W.","family":"de Jong","sequence":"first","affiliation":[{"name":"Radboudumc, Department of Pharmacy Radboud Institute for Health Sciences  P.O. 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