{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:08:47Z","timestamp":1791889727153,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T00:00:00Z","timestamp":1540425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p>Recent case reports describe an association between maternal paracetamol intake and fetal ductus arteriosus constriction or closure. To put these cases into perspective and explore causality, a structured literature search was conducted. The World Health Organization Uppsala Monitoring Centre (WHO\u2013UMC) causality tool was applied to the cases retrieved. The search resulted in 12 papers with 25 case descriptions, of which one case was classified as unlikely, nine as possible, 11 as probable and four as certain. Consequently, we concluded that a causal relationship between maternal paracetamol intake and fetal ductus arteriosus constriction or closure is likely. These findings suggest that pharmacovigilance studies on paracetamol safety during pregnancy are warranted to quantify the event and put the current findings into clinical perspective. Although analgesia during pregnancy and during the peripartum period is of obvious relevance, alternative analgesics such as opioids or other nonsteroidal anti\u2010inflammatory drugs also have side effects.<\/jats:p>","DOI":"10.1111\/bcp.13778","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T04:35:20Z","timestamp":1539146120000},"page":"245-251","source":"Crossref","is-referenced-by-count":38,"title":["Maternal paracetamol intake and fetal ductus arteriosus constriction or closure: a case series analysis"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-5105","authenticated-orcid":false,"given":"Karel","family":"Allegaert","sequence":"first","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery Erasmus MC\u2013Sophia Children's Hospital Rotterdam the Netherlands"},{"name":"Department of Pediatrics, Division of Neonatology Erasmus MC\u2013Sophia Children's Hospital Rotterdam the Netherlands"},{"name":"Department of Development and Regeneration KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3551-1201","authenticated-orcid":false,"given":"Paola","family":"Mian","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery Erasmus MC\u2013Sophia Children's Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[{"name":"Department of Neonatology H\u00f4pital Universitaire Necker Enfants Malades, Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"},{"name":"Paris Descartes University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"van den Anker","sequence":"additional","affiliation":[{"name":"Intensive Care and Department of Pediatric Surgery Erasmus MC\u2013Sophia Children's Hospital Rotterdam the Netherlands"},{"name":"Division of Pediatric Pharmacology and Pharmacometrics University Children's Hospital Basel Basel, Switzerland"},{"name":"Division of Clinical Pharmacology Children's National Health System Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2017.07.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13656"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.07.007"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02764.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.11.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102588199"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2437fje"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04402.x"},{"key":"e_1_2_8_10_1","first-page":"541","article-title":"Transplacental passage of acetaminophen in term pregnancy","volume":"34","author":"Nitsche JF","year":"2017","journal-title":"Am J Perinatol"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1555126"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-4021"},{"key":"e_1_2_8_13_1","unstructured":"World Health Organization Uppsala Monitoring Centre.The use of the WHO\u2010UMC system for standardized case causality assessment. Available athttp:\/\/www.who.int\/medicines\/areas\/quality_safety\/safety_efficacy\/WHOcausality_assessment.pdf(last accessed June 10 2018)."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G428"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"},{"key":"e_1_2_8_17_1","first-page":"350","article-title":"Conducto arterioso restricto tras el consumo de acetaminof\u00e9n [Restrictive ductus arteriosus following acetaminophen consumption]","volume":"21","author":"Ara\u00fajo JJ","year":"2014","journal-title":"Rev Colomb Cardiol"},{"issue":"1","key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/uog.16615","article-title":"Constriction of the fetal ductus arteriosus associate with high doses of paracetamol: two cases and review of the literature (P13.04)","volume":"48","author":"Capuru\u00e7o CA","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_8_19_1","first-page":"285","article-title":"Ductus arteriosus transient constriction associated with paracetamol ingestion at 32 weeks gestation","volume":"55","author":"Diez G","year":"2009","journal-title":"Rev Peru Ginecol Obstet"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-15814031"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1314876"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-008-9269-1"},{"key":"e_1_2_8_23_1","first-page":"42","article-title":"Restricci\u00f3n del ductus arterioso fetal en gestante de tercer trimestre por consumo de paracetamol [Fetal ductus arteriosus restriction in the final third of pregnancy due to acetaminophen consumption]","author":"P\u00e9rez PD","year":"2016","journal-title":"Rev Cubana Obstet Ginecol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3850"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5928"},{"issue":"1","key":"e_1_2_8_26_1","first-page":"794","article-title":"Premature constriction of fetal ductus arteriosus after maternal assumption of acetaminophen (paracetamol): report of two cases. Idiopathic or drug induced?","volume":"37","author":"Veneziano M","year":"2009","journal-title":"J Perinat Med"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/uog.2379","article-title":"Constriction and complete occlusion of the ductus arteriosus associated with maternal use of acetaminophen","volume":"26","author":"Wood D","year":"2005","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1015413"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202532"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-303688"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2011.09.023"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13778","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.13778","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13778","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:48:15Z","timestamp":1720676895000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,25]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/bcp.13778"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13778","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,25]]}}}