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Studies have shown that metformin may reduce the risk of cardiovascular disease through influences on body weight, blood pressure, cholesterol levels and the progression of atherosclerosis. Studies also suggest that metformin may be beneficial for neuro\u2010psychiatric disorders, cognitive impairment and in reducing the risk of dementia, erectile dysfunction and Duchenne muscular dystrophy.\n                    <jats:italic>In vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    studies have shown that metformin has anti\u2010cancer properties, and population studies have suggested that metformin may reduce the risk of cancer or improve cancer prognosis. It is thought that it exerts its anti\u2010cancer effect through the inhibition of the mammalian target of rapamycin (mTOR) signalling pathway. Because of its effect on the mTOR pathway, there may be a role for metformin in slowing or reversing growth of life\u2010threatening hamartomas in tuberous sclerosis complex.\n                  <\/jats:p>","DOI":"10.1111\/bcp.13780","type":"journal-article","created":{"date-parts":[[2018,10,6]],"date-time":"2018-10-06T06:13:57Z","timestamp":1538806437000},"page":"37-46","source":"Crossref","is-referenced-by-count":111,"title":["The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-2529","authenticated-orcid":false,"given":"Sam","family":"Amin","sequence":"first","affiliation":[{"name":"Paediatric Neurologist University Hospitals Bristol  Upper Maudlin Street Centre Level 6 Bristol BS28AE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lux","sequence":"additional","affiliation":[{"name":"Paediatric Neurologist 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