{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:15:18Z","timestamp":1790612118568,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to examine the level of and predictors of statin nonadherence and discontinuation among older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Among 22\u2009340 Australians aged \u226565 years who initiated statin therapy from January 2014 to December 2015, we estimated the first\u2010year nonadherence (proportion of days covered [PDC] &lt;0.80) and discontinuation (\u226590 days without statin coverage) rates. Predictors of nonadherence and discontinuation were examined via multivariable logistic regression. Analyses were performed separately for general beneficiaries (with a higher co\u2010payment; <jats:italic>n<\/jats:italic>\u00a0=\u00a04841) and concessional beneficiaries (with a lower co\u2010payment; <jats:italic>n<\/jats:italic>\u00a0=\u00a017\u2009499).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the one\u2010year follow\u2010up, 55.1% were nonadherent (concessional 52.6%; general beneficiaries 64.2%) and 44.7% discontinued statins (concessional 43.1%; general beneficiaries 50.4%). Among concessional beneficiaries, those aged 75\u201384 years and \u226585 years were more likely to discontinue than people aged 65\u201374 years (odds ratio 1.11, 95% confidence interval 1.04\u20131.19 and 1.38, 1.23\u20131.54, respectively). Diabetes was associated with an increased likelihood of nonadherence and discontinuation, while hypertension, angina and congestive heart failure were associated with a lower likelihood of nonadherence and discontinuation. Anxiety was associated with an increased likelihood of discontinuation, but polypharmacy (concurrent use of five or more drugs) was associated with a lower likelihood of nonadherence and discontinuation. Statin initiation by a general medical practitioner was associated with both increased likelihood of nonadherence and discontinuation. Similar predictors of nonadherence and discontinuation were identified for the general beneficiaries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among older adults prescribed statins, first\u2010year nonadherence and discontinuation are high. Specific population subgroups such as people aged \u226585 years, those with diabetes or anxiety may require additional attention to improve statin adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13797","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T05:01:15Z","timestamp":1541566875000},"page":"227-235","source":"Crossref","is-referenced-by-count":49,"title":["Predictors of first\u2010year nonadherence and discontinuation of statins among older adults: a retrospective cohort study"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6643-3269","authenticated-orcid":false,"given":"Richard","family":"Ofori\u2010Asenso","sequence":"first","affiliation":[{"name":"Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"},{"name":"Epidemiological Modelling Unit, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"},{"name":"Division of Metabolism, Ageing and Genomics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Ilom\u00e4ki","sequence":"additional","affiliation":[{"name":"Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences Monash University  Melbourne Australia"},{"name":"Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tacey","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-7221","authenticated-orcid":false,"given":"Si","family":"Si","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Curtis","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Ageing and Genomics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Zomer","sequence":"additional","affiliation":[{"name":"Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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