{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:58:32Z","timestamp":1775285912330,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polypharmacy of elderly oncology patients and fragmented medication management are well\u2010known risk factors for drug\u2013drug interactions (DDIs). These interactions can occur among antineoplastic, ongoing chronic treatment(s) and chemotherapy\u2010associated treatments, like antiemetics. Clinically relevant interactions based on enzyme\u2010 or transporter\u2010inhibition phenomena of active drugs can increase the frequency of their DDIs. We describe a strongly suspected elderly cancer patient's DDI between aprepitant and opium powder in the context of an irinotecan\u2010based regimen manifested by nightmares and visual hallucinations. We discuss this DDI's hypothetical pharmacological mechanisms and management.<\/jats:p>","DOI":"10.1111\/bcp.13810","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T20:10:08Z","timestamp":1543263008000},"page":"454-456","source":"Crossref","is-referenced-by-count":5,"title":["Nightmares and hallucinations with aprepitant and opium powder: a suspected drug\u2013drug interaction"],"prefix":"10.1111","volume":"85","author":[{"given":"Gr\u00e9goire","family":"Narjoux","sequence":"first","affiliation":[{"name":"Oncology Day\u2010Hospital CHU Reims Avenue General\u2010Koenig 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Clarenne","sequence":"additional","affiliation":[{"name":"Department of Pharmacy CHU Reims Avenue General\u2010Koenig 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-2445","authenticated-orcid":false,"given":"Brahim","family":"Azzouz","sequence":"additional","affiliation":[{"name":"Department of Pharmacovigilance CHU Reims Avenue General\u2010Koenig 51100 Reims France"},{"name":"Faculty of Pharmacy Reims University 51, rue Cognacq\u2010Jay 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline\u2010Sara\u00ef","family":"Zeller","sequence":"additional","affiliation":[{"name":"Oncology Day\u2010Hospital CHU Reims Avenue General\u2010Koenig 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-7034","authenticated-orcid":false,"given":"Florian","family":"Slimano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy CHU Reims Avenue General\u2010Koenig 51100 Reims France"},{"name":"Faculty of Pharmacy Reims University 51, rue Cognacq\u2010Jay 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bouch\u00e9","sequence":"additional","affiliation":[{"name":"Oncology Day\u2010Hospital CHU Reims Avenue General\u2010Koenig 51100 Reims France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70040-7"},{"key":"e_1_2_5_3_1","unstructured":"LAMALINE capsule \u2013 Summary of Product Characteristics (SPC). Available athttp:\/\/agence\u2010prd.ansm.sante.fr\/php\/ecodex\/rcp\/R0288912.htm(last accessed 16 April 2018)."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2012-007995"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.104.000216"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270003262950"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq149"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155216631408"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13322"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104215"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)60750-7"},{"key":"e_1_2_5_12_1","first-page":"1","article-title":"Human UGT2B7 catalyzes morphine glucuronidation","volume":"25","author":"Coffman BL","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.9.1086"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2015.1038743"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H423"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.14.99"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2017-0002"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0022-3565(24)37595-0","article-title":"Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)","volume":"286","author":"Zhang L","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.06.019"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13877"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.13810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13810","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.13810","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.13810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:04:01Z","timestamp":1775282641000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.13810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1111\/bcp.13810"],"URL":"https:\/\/doi.org\/10.1111\/bcp.13810","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]}}}