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To date, no cure has been identified for FD\/McCune\u2013Albright syndrome (MAS) and treatment is symptomatic and aimed at decreasing pain and\/or local bone turnover. Various drugs have been used to achieve clinical improvement in FD\/MAS patients including bisphosphonates and denosumab, however further translational studies are also warranted to address unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD\/MAS.<\/jats:p><jats:p>In this article, we review literature on the medical treatment of FD\/MAS, discuss the unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD\/MAS.<\/jats:p>","DOI":"10.1111\/bcp.13820","type":"journal-article","created":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T16:09:34Z","timestamp":1543075774000},"page":"1169-1179","source":"Crossref","is-referenced-by-count":35,"title":["Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone"],"prefix":"10.1111","volume":"85","author":[{"given":"Marlous","family":"Rotman","sequence":"first","affiliation":[{"name":"Department of 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