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Dipeptidyl peptidase\u20104 inhibitors showed neutral effects and may increase risk of heart failure. We aimed to compare cardiometabolic effects of dapagliflozin and vildagliptin in T2D patients with coronary artery disease (CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine T2D patients with CAD were randomly assigned to dapagliflozin (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) or vildagliptin (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) for 6\u00a0months in a double\u2010blind fashion. Cardiometabolic parameters were collected at baseline and at the end of treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 63.2\u00a0\u00b1\u00a07.9\u00a0years (female 46.9%). Baseline characteristics did not differ between two groups. At 6\u00a0months, HbA<jats:sub>1C<\/jats:sub> significantly decreased in both dapaglifozin and vildagliptin groups (0.6\u00a0\u00b1\u00a01.0% <jats:italic>vs<\/jats:italic> 0.8\u00a0\u00b1\u00a01.4%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.22, respectively). There was no difference between the changes in lipid profiles. Body mass index decreased in patients receiving dapagliflozin, whereas it increased in those receiving vildagliptin (\u22121.27 [95% confidence interval \u22122.01, \u22120.53] <jats:italic>vs<\/jats:italic> 1.72 [0.72, 2.72] kg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). The reduction in systolic blood pressure and high\u2010sensitivity troponin T was observed in the dapagliflozin group (\u22129.87 [\u221218.00, \u22121.15] mmHg and 2.49 [\u22124.50, \u22120.47] pg\/mL) but not in vildagliptin group (\u22121.97 [\u22129.42, 5.48] mmHg and 1.98 [\u22120.02, 3.97] pg\/mL). The mean haemoglobin increased in the dapagliflozin group, whereas the mean platelet volume increased in the vildagliptin group. There was no significant change in the inflammatory markers in both the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The extraglycaemic effects of dapagliflozin and vildagliptin on cardiometabolic parameters in T2D with CAD were different. The more favourable effects of dapagliflozin compared to vildagliptin may have explained the cardiovascular benefits observed only in sodium glucose co\u2010transporter\u20102 inhibitors<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13903","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T05:38:19Z","timestamp":1550209099000},"page":"1337-1347","source":"Crossref","is-referenced-by-count":40,"title":["Effects of dapagliflozin <i>vs<\/i> vildagliptin on cardiometabolic parameters in diabetic patients with coronary artery disease: a randomised study"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-1951","authenticated-orcid":false,"given":"Arintaya","family":"Phrommintikul","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Cardiac Electrophysiology Research and Training Center, Faculty of 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