{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:09:48Z","timestamp":1790514588525,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T00:00:00Z","timestamp":1557532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011000","name":"Mission Interminist\u00e9rielle de Lutte Contre les Drogues et les Conduites Addictives","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Our study aimed to evaluate the impacts of the cytochrome P450 (<jats:italic>CYP<\/jats:italic>) <jats:italic>2B6<\/jats:italic>\u2010<jats:italic>G516T<\/jats:italic> and <jats:italic>CYP2D6<\/jats:italic> genetic polymorphisms on pharmacokinetic and clinical parameters in patients receiving methadone maintenance treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Opioid PhArmacoLogy (OPAL) was a clinical survey of the sociodemographic characteristics, history and consequences of pathology associated with methadone maintenance treatment response and current addictive comorbidities. A subgroup of 72 methadone patients was genotyped.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When comparing the three <jats:italic>CYP2B6<\/jats:italic> genotype groups, the methadone <jats:italic>(R)<\/jats:italic>\u2010 and <jats:italic>(S)\u2010<\/jats:italic>methadone enantiomer concentrations\/doses (concentrations relative to doses) were different (<jats:italic>P<\/jats:italic> = .029, <jats:italic>P<\/jats:italic> = .0019). The CYP2D6 phenotypes did not seem to be relevant with regard to methadone levels. On multivariate analysis, neither the <jats:italic>CYP2B6<\/jats:italic> genotype nor the CYP2D6 phenotype explained the <jats:italic>(R)<\/jats:italic>\u2010methadone concentration\/dose values (<jats:italic>P<\/jats:italic>\u00a0= .92; <jats:italic>P<\/jats:italic> = .86); the <jats:italic>(S)\u2010<\/jats:italic>methadone concentration\/dose values (<jats:italic>P<\/jats:italic> = .052; <jats:italic>P<\/jats:italic> = .95 [although there was a difference between the TT group and GT and GG groups {<jats:italic>P<\/jats:italic> = .019}]); or opiate cessation (<jats:italic>P<\/jats:italic> = .12; <jats:italic>P<\/jats:italic> = .90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The genotyping of <jats:italic>CYP2B6 G516T<\/jats:italic> could be an interesting tool to explore methadone intervariability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.13936","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T11:50:22Z","timestamp":1553514622000},"page":"1538-1543","source":"Crossref","is-referenced-by-count":21,"title":["Relevance of <i>CYP2B6<\/i> and <i>CYP2D6<\/i> genotypes to methadone pharmacokinetics and response in the OPAL study"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3745-2532","authenticated-orcid":false,"given":"Caroline","family":"Victorri\u2010Vigneau","sequence":"first","affiliation":[{"name":"INSERM UMR_S1178, Team \u201cDepression and Antidepressants\u201d, Medicine Faculty, CESP Paris\u2010Sud University  Le Kremlin Bic\u00eatre France"},{"name":"INSERM UMR 1246, SPHERE, Methods in Patient\u2010Centered Outcomes and Health Research Nantes and Tours University, Nantes and Tours  France"},{"name":"Clinical Pharmacology Department  CHU Nantes Nantes 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