{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:12Z","timestamp":1790136132330,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T00:00:00Z","timestamp":1561161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Intravenous flucloxacillin is one of the most frequently used high\u2010dose penicillin therapies in hospitalized patients, forming the cornerstone treatment of invasive <jats:styled-content style=\"fixed-case\"><jats:italic>Staphylococcus aureus<\/jats:italic><\/jats:styled-content> infection. Being a nonreabsorbable anion, flucloxacillin has been suggested to cause hypokalaemia, although the frequency and magnitude of this unwanted effect is unknown. In a retrospective cohort, we investigated the incidence and extent of hypokalaemia after initiation of intravenous flucloxacillin or ceftriaxone therapy. In total, 77 patients receiving flucloxacillin (62% male, mean age 70.5\u00a0years) and 84 patients receiving ceftriaxone (46% male, mean age 70.8\u00a0years) were included. Hypokalaemia occurred significantly more often in patients receiving flucloxacillin than ceftriaxone (42% <jats:italic>vs<\/jats:italic> 14%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a010<jats:sup>\u22124<\/jats:sup>). Moreover, follow\u2010up potassium levels were significantly lower during flucloxacillin therapy. In general, women were more prone to develop hypokalaemia than men. In conclusion, intravenous flucloxacillin use is associated with a striking incidence of hypokalaemia. Therefore, standardized potassium measurements are necessary.<\/jats:p>","DOI":"10.1111\/bcp.13969","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T18:33:32Z","timestamp":1556303612000},"page":"2886-2890","source":"Crossref","is-referenced-by-count":17,"title":["Intravenous flucloxacillin treatment is associated with a high incidence of hypokalaemia"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-3107","authenticated-orcid":false,"given":"Charlotte D.C.C.","family":"van der Heijden","sequence":"first","affiliation":[{"name":"Dept. of Internal Medicine Canisius Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen L.","family":"Duizer","sequence":"additional","affiliation":[{"name":"Dept. of Internal Medicine Canisius Wilhelmina Hospital  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke 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