{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:52:56Z","timestamp":1790704376041,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M008770\/1"],"award-info":[{"award-number":["BB\/M008770\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Cannabidiol (CBD) is a cannabis\u2010derived medicinal product with potential application in a wide\u2010variety of contexts; however, its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of CBD in a variety of medical contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Publications involving administration of CBD alone were collected by searching PubMed, EMBASE and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1038 articles were retrieved, of which 35 studies met inclusion criteria covering 13 medical contexts. Twenty\u2010three studies reported a significant improvement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), with doses ranging between &lt;1 and 50\u00a0mg\/kg\/d. Plasma concentrations were not provided in any publication. CBD was reported as well tolerated and epilepsy was the most frequently studied medical condition, with all 11 studies demonstrating positive effects of CBD on reducing seizure frequency or severity (average 15\u00a0mg\/kg\/d within randomised controlled trials). There was no signal of positive activity of CBD in small randomised controlled trials (range\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06\u201362) assessing diabetes, Crohn's disease, ocular hypertension, fatty liver disease or chronic pain. However, low doses (average 2.4\u00a0mg\/kg\/d) were used in these studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review highlights that CBD has a potential wide range of activity in several pathologies. Pharmacokinetic studies as well as conclusive phase III trials to elucidate effective plasma concentrations within medical contexts are severely lacking and highly encouraged.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14038","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T01:05:02Z","timestamp":1561079102000},"page":"1888-1900","source":"Crossref","is-referenced-by-count":220,"title":["A systematic review of cannabidiol dosing in clinical populations"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1318-7671","authenticated-orcid":false,"given":"S.A.","family":"Millar","sequence":"first","affiliation":[{"name":"Division of Medical Sciences and Graduate Entry Medicine, School of Medicine University of Nottingham, Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.L.","family":"Stone","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences and Graduate Entry Medicine, School of Medicine University of Nottingham, Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.D.","family":"Bellman","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences and Graduate Entry Medicine, School of Medicine University of Nottingham, Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.S.","family":"Yates","sequence":"additional","affiliation":[{"name":"Artelo Biosciences  La Jolla CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"England","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences and Graduate Entry Medicine, School of Medicine University of Nottingham, Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.E.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences and Graduate Entry Medicine, School of Medicine University of Nottingham, Royal Derby Hospital  Derby UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO.Cannabidiol (CBD): World Health Organisation Expert Committee on Drug Dependence Thirty\u2010ninth Meeting.2017. 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