{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:32:20Z","timestamp":1787164340778,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The comparative efficacy, safety and tolerability of budesonide\u2010MMX and oral mesalamine in active, mild\u2010to\u2010moderate ulcerative colitis (UC) are unclear. We conducted a network meta\u2010analysis to fill this evidence gap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Scopus, Embase, the Cochrane Library, clinical trial registries, regulatory agencies' websites and international conference proceedings, up to July 2018, to identify randomized controlled trials of adult patients with active, mild\u2010to\u2010moderate UC, comparing budesonide\u2010MMX or mesalamine against placebo, or against each other, or different dosing strategies, for induction of remission. Two reviewers independently abstracted study data and outcomes, and assessed each trial's risk\u2010of\u2010bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified and synthesized evidence from 15 eligible trials including 4083 participants. Budesonide\u2010MMX 9\u00a0mg\/day and mesalamine &gt;2.4\u00a0g\/day had similar efficacy for induction of clinical and endoscopic remission (OR\u00a0=\u00a00.97; 0.59\u20131.60), both showing superiority over placebo (OR\u00a0=\u00a02.68; 1.75\u20134.10, and OR\u00a0=\u00a02.75; 1.94\u20133.90, respectively). Furthermore, mesalamine &gt;2.4\u00a0g\/day was more efficacious than mesalamine 1.6\u20132.4\u00a0g\/day (odds ratio\u00a0=\u00a01.27; 1.03\u20131.56). Secondary analyses showed that mesalamine &gt;2.4\u00a0g\/day ranks at the top among comparator treatments regarding safety (serious adverse events; surface under the cumulative ranking area [SUCRA] 79.2%) and tolerability (treatment discontinuations or withdrawals from the study due to adverse events; SUCRA 96.7%). There was no evidence of inconsistency, while heterogeneity between studies and risk of publication bias were low.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Budesonide\u2010MMX and mesalamine &gt;2.4\u00a0g\/day had similar efficacy for induction of clinical and endoscopic remission in active, mild\u2010to\u2010moderate UC; however, mesalamine &gt;2.4\u00a0g\/day showed better tolerability. Further high\u2010quality research is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14051","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T16:13:03Z","timestamp":1562170383000},"page":"2244-2254","source":"Crossref","is-referenced-by-count":16,"title":["Comparative assessment of budesonide\u2010MMX and mesalamine in active, mild\u2010to\u2010moderate ulcerative colitis: A systematic review and network meta\u2010analysis"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IBD Center, Department of Gastroenterology Humanitas Clinical and Research Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios K.","family":"Nikolopoulos","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Piovani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IBD Center, Department of Gastroenterology Humanitas Clinical and Research Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marien","family":"Gonz\u00e1lez\u2010Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IBD Center, Department of Gastroenterology Humanitas Clinical and Research Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Pantavou","sequence":"additional","affiliation":[{"name":"Medical School University of Cyprus  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Lytras","sequence":"additional","affiliation":[{"name":"Hellenic Center for Disease Control and Prevention  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin\u2010Biroulet","sequence":"additional","affiliation":[{"name":"Department of Hepato\u2010Gastroenterology and Inserm U954 University Hospital of Nancy, University of Lorraine  Vandoeuvre\u2010l\u00e8s\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Milan Italy"},{"name":"IBD Center, Department of Gastroenterology Humanitas Clinical and Research Center  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.727"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.06.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0396-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13456"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f2914"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.331.7521.897"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.04.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.01.011"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2385"},{"key":"e_1_2_8_15_1","first-page":"2031","article-title":"Are there any differences in the efficacy and safety of different formulations of oral 5\u2010ASA used for induction and maintenance of remission in ulcerative colitis? 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