{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:41:37Z","timestamp":1792024897708,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Drug\u2010induced aseptic meningitis (DIAM) is an adverse drug reaction of exclusion; only few studies have addressed this iatrogenic disease. The aim was to characterize DIAM and to identify suspected drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were collected from the analysis of the French Pharmacovigilance Database from inception (1 January 1985) to 8 March 2017. All cases were initially analysed according to the French imputability method by institutional pharmacologists (clinicians or pharmacists). Further analyses of well documented cases were then performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In this study, 329 cases of aseptic meningitis were retrieved from the French Pharmacovigilance Database for a total of 429 suspected drugs. Analysis of 203 well documented cases, including 282 drugs, showed that the main reported classes were intravenous polyvalent immunoglobulin, nonsteroidal anti\u2010inflammatory drugs (NSAIDs), vaccines, antimicrobials, intrathecal antimetabolites, corticosteroids and antalgics\/anaesthetics (except NSAIDs).\n                      <jats:italic>Lymphocytic<\/jats:italic>\n                      (33.0%) and\n                      <jats:italic>purulent<\/jats:italic>\n                      (44.8%) meningitis represented the majority of cases of aseptic meningitis. In other cases, the cerebrospinal fluid was mixed (45\u201355% of neutrophils +45\u201355% of lymphocytes) or data about cerebrospinal fluid composition were lacking. Most DIAM cases (96%) had a favourable reported outcome with full recovery or minimal residual symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The most frequently involved drugs in DIAM were intravenous polyvalent immunoglobulin, NSAIDs, vaccines, and antimicrobials and this without being able to differentiate them in terms of biological characteristics. Although further studies are needed to better understand the pathophysiological mechanisms of DIAM, a continuous enrichment of pharmacovigilance databases is essential to identify new signals and to help clinicians in the understanding of DIAM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bcp.14073","type":"journal-article","created":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T06:31:10Z","timestamp":1563431470000},"page":"2540-2546","source":"Crossref","is-referenced-by-count":36,"title":["Drug\u2010induced aseptic meningitis: 329 cases from the French pharmacovigilance database analysis"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6797-0237","authenticated-orcid":false,"given":"Kevin","family":"Bihan","sequence":"first","affiliation":[{"name":"Regional Pharmacovigilance Center, Department of Pharmacology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Weiss","sequence":"additional","affiliation":[{"name":"Brain Liver Piti\u00e9\u2010Salp\u00eatri\u00e8re (BLIPS) Study Group, Assistance Publique\u2014H\u00f4pitaux de Paris, Groupement Hospitalier Piti\u00e9\u2010Salp\u00eatri\u00e8re\u2010Charles Foix, D\u00e9partement de Neurologie, Unit\u00e9 de r\u00e9animation neurologique Sorbonne Universit\u00e9  Paris France"},{"name":"INSERM, Centre de Recherche Saint\u2010Antoine (CRSA) Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Th\u00e9ophile","sequence":"additional","affiliation":[{"name":"Regional Pharmacovigilance Center, Department of Pharmacology Bordeaux Hospital  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Funck\u2010Brentano","sequence":"additional","affiliation":[{"name":"INSERM, CIC\u20101421 and UMR ICAN 1166, Sorbonne Universit\u00e9, Faculty of Medicine, AP\u2010HP, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, Department of Pharmacology and Clinical Investigation Center Institute of Cardiometabolism and Nutrition (ICAN)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6676-5063","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Lebrun\u2010Vignes","sequence":"additional","affiliation":[{"name":"Regional Pharmacovigilance Center, Department of Pharmacology Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8]]},"reference":[{"issue":"12","key":"e_1_2_10_2_1","first-page":"1491","article-title":"Diagnosis, initial management, and prevention of meningitis","volume":"82","author":"Bamberger DM","year":"2010","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_3_1","volume-title":"Principles of Neurology","author":"Adams RD","year":"1997"},{"issue":"5","key":"e_1_2_10_4_1","first-page":"314","article-title":"Aseptic and bacterial meningitis: evaluation, treatment, and prevention","volume":"96","author":"Mount HR","year":"2017","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_5_1","volume-title":"Clinical Epidemiology: The Architecture of Clinical Research","author":"Feinstein AR","year":"1985"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"111","article-title":"Imputation of the unexpected or toxic effects of drugs. 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