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Our objectives were (a) to describe a pheochromocytoma crisis, (b) to investigate in vivo myocardial depressant activities for the N\u2010terminal 1\u201076 Chromogranin A\u2010derived peptide, vasostatin\u2010I (VS\u2010I). A patient with a pheochromocytoma crisis was treated, including extracorporeal membrane oxygenation, until mass resection. Plasma concentrations of VS\u2010I were time\u2010dependently assessed with a specific immunoassay; correlations with invasive cardiovascular parameters were investigated. Increased VS\u2010I concentrations were observed over 7 days until tumour resection. VS\u2010I concentrations correlated positively with Chromogranin A levels, negatively with cardiac output and left ventricular stroke work index, but not with heart rate. This case illustrates the pharmacokinetics of VS\u2010I in a pheochromocytoma crisis. It highlights myocardial depressant activity for this peptide at high concentrations.<\/jats:p>","DOI":"10.1111\/bcp.14173","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T18:51:47Z","timestamp":1573757507000},"page":"825-828","source":"Crossref","is-referenced-by-count":1,"title":["Adrenal gland\u2010released vasostatin\u2010I is a myocardial depressant factor"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7481-5101","authenticated-orcid":false,"given":"Francis","family":"Schneider","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive\u2010R\u00e9animation  H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg France"},{"name":"Inserm UMR 1121, Facult\u00e9 de Chirurgie Dentaire, H\u00f4pital Civil, 1 Place de l'H\u00f4pital Strasbourg France"},{"name":"F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg, Facult\u00e9 de M\u00e9decine, Rue 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