{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:27:30Z","timestamp":1790767650628,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T00:00:00Z","timestamp":1582588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Breast cancer is the most frequently occurring cancer in women. Lumpectomy followed by radiotherapy is suggested to be as effective as a total mastectomy. Radiation\u2010induced dermatitis often occurs as a result of breast radiotherapy. Recent studies suggest that doxepin has promising anti\u2010inflammatory properties. This study was undertaken to evaluate the effects of doxepin therapy on radiation dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind randomized clinical trial was launched from 2016 to 2017, with a total of 48 patients who had undergone breast\u2010conserving surgery and received postoperative radiation therapy. Radiotherapy was applied 5 days per week for 5 weeks. Adverse dermatological effects were evaluated by a physician at the beginning of the fifth week of radiotherapy and the patients were then randomly assigned (1:1 ratio) to receive either doxepin (5%) or placebo cream for 7 days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the dermatitis grade between doxepin and placebo groups at baseline (<jats:italic>P<\/jats:italic> &gt; .5). The occurrence of acute dermatitis (grade 2 or higher) was significantly lower with the use of doxepin than with placebo (<jats:italic>P<\/jats:italic> \u2264 .0001, <jats:italic>Z<\/jats:italic><jats:sub><jats:italic>\u03b1<\/jats:italic><\/jats:sub> = 1.96 at 95% confidence interval).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Doxepin cream prevents dermatitis grade 2 or higher during post\u2010operative breast irradiation. Doxepin cream is easy to use, affordable and prevents pain and irritation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14238","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T19:03:54Z","timestamp":1581361434000},"page":"1875-1881","source":"Crossref","is-referenced-by-count":12,"title":["Protective effects of doxepin cream on radiation dermatitis in breast cancer: A single arm double\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"86","author":[{"given":"Laleh","family":"Shariati","sequence":"first","affiliation":[{"name":"Applied Physiology Research Center, Cardiovascular Research Institute, Department of Physiology Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine Isfahan University of Medical Sciences  Isfahan 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