{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:42:18Z","timestamp":1790502138906,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T00:00:00Z","timestamp":1589068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French National Agency for Medicines and Health Products Safety","award":["2014S029"],"award-info":[{"award-number":["2014S029"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>This article sought to study the association between patterns of benzodiazepine (BZD) use and the risk of hip and forearm fractures in people aged 50 and 75 years or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a representative cohort of the French National Health Insurance Fund of individuals aged 50 years or older (<jats:italic>n<\/jats:italic> = 106 437), we followed up BZD dispensing (reflecting their patterns of use) and the most frequent fall\u2010related fractures (hip and forearm) for 8 years. We used joint latent class models to simultaneously identify BZD dispensing trajectories and the risk of fractures in the entire cohort and in those 75 years or older). We used a survival model to estimate the adjusted hazard ratios (aHRs) between these trajectories and the risk of fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the entire cohort, we identified 5 BZD trajectories: <jats:italic>non\u2010users<\/jats:italic> (76.7% of the cohort); <jats:italic>occasional users<\/jats:italic> (15.2%); <jats:italic>decreasing users<\/jats:italic> (2.6%); <jats:italic>late increasing users<\/jats:italic> (3.0%); and <jats:italic>early increasing users<\/jats:italic> (2.4%). Compared with non\u2010users, fracture risk was not increased in either occasional users (aHR = 0.99, 95% confidence interval [CI] 0.99\u20131.00) or in decreasing users (aHR = 0.90, 95% CI 0.74\u20131.08). It was significantly higher in early increasing users (aHR = 1.86, 95% CI 1.62\u20132.14) and in late increasing users (aHR = 1.39, 95% CI 1.15\u20131.60). We observed similar trajectories and risk levels in the people older than 75 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Occasional BZD use, which is compatible with current recommendations, was not associated with an excess risk of the most frequent fall\u2010related fractures in people older than 50 or 75 years.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14307","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T09:53:29Z","timestamp":1586858009000},"page":"2155-2164","source":"Crossref","is-referenced-by-count":7,"title":["Long\u2010term risk of hip or forearm fractures in older occasional users of benzodiazepines"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-9863","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Carrier","sequence":"first","affiliation":[{"name":"Aix Marseille Univ, IRD, AP\u2010HM, SSA, VITROME  Marseille France"},{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection  Marseille France"},{"name":"Department of General Practice, Aix\u2010Marseille University  Marseille France"},{"name":"ORS Paca, Regional Health Observatory  Provence\u2010Alpes\u2010C\u00f4te d'Azur Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Cortaredona","sequence":"additional","affiliation":[{"name":"Aix Marseille Univ, IRD, AP\u2010HM, SSA, VITROME  Marseille France"},{"name":"IHU\u2010M\u00e9diterran\u00e9e Infection  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Philipps","sequence":"additional","affiliation":[{"name":"Univ. 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