{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:58:13Z","timestamp":1785214693540,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>High dose melphalan (HDM) and autologous stem cell transplant (ASCT) is standard of care for multiple myeloma (MM), but there is significant variability in melphalan exposure (area under the plasma drug concentration\u2013time curve, AUC) when using body surface area\u2010based dosing. Our aim was to establish a method of pharmacokinetic (PK) testing for real\u2010time melphalan dose adjustments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a prospective PK study of melphalan 140 or 200 mg\/m<jats:sup>2<\/jats:sup> in MM patients undergoing ASCT. Twenty MM patients were administered HDM on days \u22122 and \u2212 1, with PK sampling at 8\u201310 time points. PK testing was performed on day \u22122 in all patients, and on day \u22121 in 5 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Less than 20% interpatient variation in the day \u22122 and \u2212 1 AUC was observed. The day \u22122 range in AUC (4.95\u201311.28 mg h\/L) confirmed significant interpatient variability. The hypothetical total dose ranged from 133\u2013302 mg\/m<jats:sup>2<\/jats:sup> to achieve the total median AUC. A 4\u2010time point AUC (0, 30, 150 and 240 min) highly correlated with the AUC from the 8\u2010time point schedule. A higher AUC correlated with increased risk of febrile neutropenia (<jats:italic>P =<\/jats:italic> .05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Here we outline the methods to establish novel melphalan dosing using PK testing in MM patients undergoing ASCT to target a desired melphalan AUC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14308","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T09:52:28Z","timestamp":1586857948000},"page":"2165-2173","source":"Crossref","is-referenced-by-count":6,"title":["Development of a method for clinical pharmacokinetic testing to allow for targeted Melphalan dosing in multiple myeloma patients undergoing autologous transplant"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9559-0282","authenticated-orcid":false,"given":"Karen","family":"Sweiss","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice University of Illinois at 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