{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:26:09Z","timestamp":1773923169517,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:p>A 66\u2010year\u2010old woman diagnosed clinical manifestation of extensive hard palate hyperpigmentation is presented. Due to historic of rheumatoid arthritis and use of chloroquine phosphate for 3 years, exogenous hyperpigmentation associated with the drug was included among the possible diagnoses. Incisional biopsy was performed and the histopathological exam confirmed exogenous hyperpigmentation compatible with chloroquine use. The patient was referred to the rheumatologist and the ophthalmologist for evaluation of the continuity of the chloroquine use. After one year of follow\u2010up, no changes were seen in the hyperpigmentation nor other clinical changes. Hyperpigmentation of the hard palate by the use of chloroquine is one of the adverse effects of the chronic use of this drug and does not require specific treatment. The adequate anamnesis and the knowledge about the adverse effects of the drug allowed an adequate therapeutic approach in the case.<\/jats:p>","DOI":"10.1111\/bcp.14313","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T07:00:39Z","timestamp":1587366039000},"page":"2325-2327","source":"Crossref","is-referenced-by-count":14,"title":["Extensive hard palate hyperpigmentation associated with chloroquine use"],"prefix":"10.1111","volume":"86","author":[{"given":"G\u00e9ssica Vasconcelos","family":"Godinho","sequence":"first","affiliation":[{"name":"Mato Grosso Cancer Hospital, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luiza Lima Medeiros","family":"Paz","sequence":"additional","affiliation":[{"name":"Mato Grosso Cancer Hospital, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u00e2ine Patr\u00edcia Alves","family":"de Ara\u00fajo Gomes","sequence":"additional","affiliation":[{"name":"University of Cuiab\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Loreda","family":"Garcia","sequence":"additional","affiliation":[{"name":"University of Cuiab\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2969-1963","authenticated-orcid":false,"given":"Luiz Evaristo Ricci","family":"Volpato","sequence":"additional","affiliation":[{"name":"University of Cuiab\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_1_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-011-0288-5"},{"key":"e_1_2_1_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.163471"},{"key":"e_1_2_1_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104762"},{"key":"e_1_2_1_7_5_1","doi-asserted-by":"publisher","DOI":"10.5582\/ddt.2020.01012"},{"key":"e_1_2_1_7_6_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2020.01047"},{"key":"e_1_2_1_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa237"},{"issue":"10","key":"e_1_2_1_7_8_1","first-page":"682","article-title":"Pigmented lesions of the oral cavity: review, differential diagnosis, and case presentations","volume":"70","author":"Kauzman A","year":"2004","journal-title":"J Can Dent Assoc"},{"issue":"12","key":"e_1_2_1_7_9_1","first-page":"e1487","article-title":"Hyperpigmentation of hard palate induced by chloroquine therapy","volume":"9","author":"Andrade BA","year":"2017","journal-title":"J Clin Exp Dent"},{"key":"e_1_2_1_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105923"},{"issue":"1","key":"e_1_2_1_7_11_1","first-page":"1","article-title":"Pathological pigmentation of the skin and palate caused by continuous use of chloroquine: case report","volume":"2","author":"Ferrazzo KL","year":"2017","journal-title":"J Oral Diag"},{"key":"e_1_2_1_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2017.06.003"},{"key":"e_1_2_1_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.106340"},{"key":"e_1_2_1_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2017.10.006"},{"key":"e_1_2_1_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12182"},{"key":"e_1_2_1_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.07.022"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.14313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14313","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.14313","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14313","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T13:01:13Z","timestamp":1693832473000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/bcp.14313"],"URL":"https:\/\/doi.org\/10.1111\/bcp.14313","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]}}}