{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:27:55Z","timestamp":1784554075765,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Evidence on acute respiratory failure (ARF) from antipsychotics is scant, and only 1 population\u2010based study examined this drug safety issue in chronic obstructive pulmonary disease patients. Antipsychotics have been frequently prescribed off\u2010label in adults, but whether antipsychotic use carries an increased ARF risk among adult patients is uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We adopted a nested case\u2013control study analysing 716 493 adults aged \u226520 years, identified from the Taiwan nationwide healthcare claims records between January 2000 and December 2013. Among the study cohort, 7084 adults with ARF and 12,785 disease risk scored\u2010matched randomly selected controls were analysed. Multivariable logistic regression models were employed to estimate odds ratios of ARF with antipsychotic usages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Current, recent, and recent past use of antipsychotics was associated with a 2.33\u2010fold (95% confidence interval [CI] = 2.06\u20132.64), 1.79\u2010fold (95% CI = 1.43\u20132.25) and 1.41\u2010fold (95% CI = 1.20\u20131.66) increased risk of ARF, respectively, compared with nonuse, while antipsychotics discontinued &gt;90 days carried no risk. A dose\u2010dependent association was observed with current therapy of antipsychotics (test for trend,<jats:italic>P<\/jats:italic>&lt; .001), in which antipsychotic use at &gt;1 defined daily dose yielded the highest risk of 6.53\u2010fold (95% CI = 3.33\u201312.79). The findings were robust to using carbamazepine as an active comparator.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antipsychotic use was associated with an increased risk of ARF in adult patients. The risk was dose\u2010dependent and markedly higher with current use of antipsychotic agents at doses of 1 defined daily dose and above, &lt;10% of this cohort. Physicians should be vigilant about any respiratory symptoms in patients currently receiving antipsychotics at such dose.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14321","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T04:14:35Z","timestamp":1587960875000},"page":"2204-2216","source":"Crossref","is-referenced-by-count":19,"title":["Use of antipsychotics and the risk of acute respiratory failure among adults: A disease risk score\u2010matched nested case\u2013control study"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-6632","authenticated-orcid":false,"given":"Meng\u2010Ting","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy National Defense Medical Center Taipei Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen Wei","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Pharmacy National Defense Medical Center 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