{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:33:45Z","timestamp":1791524025111,"version":"4.3.4"},"reference-count":107,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000950","name":"Cancer Council South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001102","name":"Cancer Council NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>There are few fields of medicine in which the individualisation of medicines is more important than in the area of oncology. Under\u2010dosing can have significant ramifications due to the potential for therapeutic failure and cancer progression; by contrast, over\u2010dosing may lead to severe treatment\u2010limiting side effects, such as agranulocytosis and neutropenia. Both circumstances lead to poor patient prognosis and contribute to the high mortality rates still seen in oncology. The concept of dose individualisation tailors dosing for each individual patient to ensure optimal drug exposure and best clinical outcomes. While the value of this strategy is well recognised, it has seen little translation to clinical application. However, it is important to recognise that the clinical setting of oncology is unlike that for which therapeutic drug monitoring (TDM) is currently the cornerstone of therapy (e.g. antimicrobials). Whilst there is much to learn from these established TDM settings, the challenges presented in the treatment of cancer must be considered to ensure the implementation of TDM in clinical practice. Recent advancements in a range of scientific disciplines have the capacity to address the current system limitations and significantly enhance the use of anticancer medicines to improve patient health. This review examines opportunities presented by these innovative scientific methodologies, specifically sampling strategies, bioanalytics and dosing decision support, to enable optimal practice and facilitate the clinical implementation of TDM in oncology.<\/jats:p>","DOI":"10.1111\/bcp.14372","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T06:57:30Z","timestamp":1589957850000},"page":"227-236","source":"Crossref","is-referenced-by-count":49,"title":["Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0855-5081","authenticated-orcid":false,"given":"Bradley D.","family":"Menz","sequence":"first","affiliation":[{"name":"SA Pharmacy Flinders Medical Centre  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-587X","authenticated-orcid":false,"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology St Vincent's Hospital  Sydney NSW Australia"},{"name":"St. Vincent's Clinical School University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Verougstraete","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Ghent University Hospital  Ghent Belgium"},{"name":"Laboratory of Toxicology, Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Kocic","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology &amp; Toxicology St Vincent's Hospital  Sydney NSW Australia"},{"name":"St. Vincent's Clinical School University of New South Wales  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Galettis","sequence":"additional","affiliation":[{"name":"Faculty of Health and Medicine University of Newcastle  Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-348X","authenticated-orcid":false,"given":"Christophe P.","family":"Stove","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology, Faculty of Pharmaceutical Sciences Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-7287","authenticated-orcid":false,"given":"Stephanie E.","family":"Reuter","sequence":"additional","affiliation":[{"name":"UniSA Clinical &amp; Health Sciences University of South Australia  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-010-0913-y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2160-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-8-913"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199902000-00010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.04.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.04.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.04.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-014-2599-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.194"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000141"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1255"},{"key":"e_1_2_9_13_1","first-page":"2039","article-title":"Clinical impact of pharmacokinetically\u2010guided dose adaptation of 5\u2010fluorouracil: results from a multicentric randomized trial in patients with locally advanced head and neck carcinomas","volume":"4","author":"Fety R","year":"1998","journal-title":"Clin Cancer Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.3934"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1470"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr.2017.10.30"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1124"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4159"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4780"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.787"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmpk.2018.11.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000681"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.12.040"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802025-8.00013-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.12.103"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200645030-00006"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.11.032"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.02.051"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2011.10.003"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000013"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.03.040"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2017-0059"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.3909"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.07.012"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2018.06.026"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-647834"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2013.190"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.02.057"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2012.06.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.07.010"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.13.156"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0177-7"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2014.10.040"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-2999-2"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.07.018"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/scipharm86020018"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.6241"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000673"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.07.008"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143421"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.02.020"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1706"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.05.011"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.10.007"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-009-2775-z"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.11.079"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.101"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12757"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225225"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.07.011"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.728"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.14.171"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12801"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-6440-6"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-019-02640-1"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.10.010"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.008"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.004"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5022562"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0411"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b03512"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b03179"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio.15.98"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-019-01868-1"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.4155\/bio-2018-0228"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121741"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000643"},{"key":"e_1_2_9_78_1","unstructured":"Centers for Disease Control and Prevention.Clinical Laboratory Improvement Amendments (CLIA).https:\/\/www.cdc.gov\/clia\/Accessed 7 February2020."},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2016.05.001"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10040221"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00040-2016"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)30114-4"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2015.00020"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-014-0137-2"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1893"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0394-3"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-009-1170-y"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000102"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.656"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4811-9_69"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0061"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008315318"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802193380803"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01653-13"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000690"},{"key":"e_1_2_9_96_1","article-title":"Inability of current dosing to achieve carboplatin therapeutic targets in people with advanced non\u2010small cell lung cancer: impact of systemic Inlammation on carboplatin exposure and clinical outcomes","author":"Harris BDW","journal-title":"Clin Pharmacokinet"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)01034-9"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0727-5"},{"key":"e_1_2_9_99_1","unstructured":"DoseMeRx Pty Ltd.DoseMeRx Platform.https:\/\/doseme-rx.com\/our-platform. Accessed 7 February2020."},{"key":"e_1_2_9_100_1","unstructured":"InsightRx Inc.Drug Modules.https:\/\/www.insight-rx.com\/product\/drug-modules. Accessed 7 February2020."},{"key":"e_1_2_9_101_1","unstructured":"TDMx.Launch Pad.http:\/\/www.tdmx.eu\/Launch-TDMx\/. Accessed 7 February2020."},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14066"},{"key":"e_1_2_9_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.2.401"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.044727"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-012-9614-6"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.2196\/mededu.7719"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpp.12499"},{"key":"e_1_2_9_108_1","article-title":"Education to improve vancomycin use \u2010 the perspectives of educators and education recipients","author":"Dort BA","journal-title":"Intern Med J"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.14372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.14372","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:46:40Z","timestamp":1693212400000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":107,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/bcp.14372"],"URL":"https:\/\/doi.org\/10.1111\/bcp.14372","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}