{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T01:54:45Z","timestamp":1776995685146,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1C1B5015912"],"award-info":[{"award-number":["2017R1C1B5015912"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Phosphate\u2010lowering effects of ferric citrate were reported in several clinical trials, but mostly in small\u2010scale studies. The aim of this meta\u2010analysis was to investigate the efficacy and safety of ferric citrate in controlling hyperphosphataemia and iron\u2010deficiency anaemia in chronic kidney disease (CKD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Embase and Cochrane Library were searched for clinical trials that enrolled CKD patients receiving ferric citrate for hyperphosphataemia. Two investigators performed systematic literature search to identify eligible studies, evaluated risk of bias and extracted relevant data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen studies were included in the meta\u2010analysis. Phosphate\u2010lowering effects of ferric citrate were greater compared to no active treatment (standardized mean difference [SMD] = \u22121.15; <jats:italic>P<\/jats:italic> &lt; 0.001) and comparable to other phosphate binders (SMD = 0.03; <jats:italic>P<\/jats:italic> = 0.61). Calcium concentrations post ferric citrate treatment did not differ compared to no active treatment (SMD = 0.15; <jats:italic>P<\/jats:italic> = 0.21) but were significantly lower compared to other phosphate binders (SMD = \u22120.14; <jats:italic>P<\/jats:italic> = 0.01). These led to significant reductions in calcium\u2010phosphorus product with ferric citrate versus no active control (SMD = \u22121.02; <jats:italic>P<\/jats:italic> &lt; 0.001) but no difference versus active control (SMD = \u22120.01; <jats:italic>P<\/jats:italic> = 0.93). Intact parathyroid hormone showed no substantial between\u2010group difference in both comparison against no active and active controls. Ferric citrate improved iron stores and anaemia parameters, but increased risk of diarrhoea, abdominal pain and discoloured faeces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ferric citrate was effective in lowering phosphorus and phosphorus\u2010calcium product versus no active treatment and had comparable effects versus other phosphate binders. Calcium levels were significantly lower with ferric citrate than with other phosphate\u2010lowering treatment. Ferric citrate had additive effects on iron repletion and anaemia control and was associated with mostly gastrointestinal side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14396","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T20:14:21Z","timestamp":1590783261000},"page":"414-426","source":"Crossref","is-referenced-by-count":13,"title":["Ferric citrate in the management of hyperphosphataemia and iron deficiency anaemia: A meta\u2010analysis in patients with chronic kidney disease"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-4374","authenticated-orcid":false,"given":"Yeo Jin","family":"Choi","sequence":"first","affiliation":[{"name":"Clinical Trial Center Hallym University Hospital  Anyang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-5092","authenticated-orcid":false,"given":"Yoojin","family":"Noh","sequence":"additional","affiliation":[{"name":"Massachusetts College of Pharmacy and Health Sciences  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2388-1122","authenticated-orcid":false,"given":"Sooyoung","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy Ajou University  Suwon Republic of Korea"},{"name":"Research Institute of Pharmaceutical Science and Technology (RIPST) Ajou University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2015.01.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2008.01.008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5414\/CN109265"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9531176"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070602"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.09.021"},{"key":"e_1_2_10_8_1","first-page":"279","article-title":"KDIGO clinical practice guideline for anemia in chronic kidney disease","volume":"2","author":"Kidney Disease Global Outcomes (KDIGO) Anemia Work Group","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0912522"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2016.01.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847090-00001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.05.015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061274"},{"key":"e_1_2_10_14_1","volume-title":"Auryxia (ferric citrate) [package insert]","year":"2017"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016101053"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21990"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1793"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3129\/i08-001"},{"issue":"7454","key":"e_1_2_10_21_1","first-page":"1","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"Atkins D","year":"2004","journal-title":"BMJ"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.10.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018101016"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0188712"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.11.041"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40620-014-0108-6"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020212"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489964"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341922"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.03.013"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.2.265"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000344008"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft483"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000366482"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05170513"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2014.03.006"},{"key":"e_1_2_10_38_1","first-page":"1","article-title":"Phosphate binders for preventing and treating chronic kidney disease\u2010mineral and bone disorder (CKD\u2010MBD)","volume":"8","author":"Ruospo M","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.006"},{"key":"e_1_2_10_40_1","first-page":"136","article-title":"KIDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"3","author":"Kidney Disease Improving Global Outcomes (KDIGO) CKD Work Group","year":"2013","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kisu.2017.04.001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S71559"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-6686.2009.00051.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2019.05.002"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4155\/cli.14.54"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.761599"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1100\/2012\/846824"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080842"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0043"}],"container-title":["British Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbcp.14396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14396","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bcp.14396","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bcp.14396","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:43:41Z","timestamp":1693212221000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bcp.14396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/bcp.14396"],"URL":"https:\/\/doi.org\/10.1111\/bcp.14396","archive":["Portico"],"relation":{},"ISSN":["0306-5251","1365-2125"],"issn-type":[{"value":"0306-5251","type":"print"},{"value":"1365-2125","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}