{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:44:25Z","timestamp":1772779465206,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T00:00:00Z","timestamp":1593907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014476","name":"Pfizer Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014476","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate whether 2 years of treatment with bisphosphonates in combination with calcium\/vitamin D supplements has an effect on lumbar spine and hip bone mineral density (BMD) in ankylosing spondylitis (AS) patients starting tumour necrosis factor\u2010\u03b1 inhibitors or receiving conventional treatment. Secondly, to explore the development of radiographic vertebral fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients from the Groningen Leeuwarden AS cohort receiving bisphosphonates based on clinical indication and available 2\u2010year follow\u2010up BMD measurements were included. BMD of lumbar spine (L1\u2013L4) and hip (total proximal femur) were measured using dual\u2010energy X\u2010ray absorptiometry. Spinal radiographs (Th4\u2013L4) were scored for vertebral fractures according to the Genant method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 20 included patients (median 52 years, 14 males), lumbar spine and hip BMD Z\u2010scores increased significantly; median from \u22121.5 (interquartile range [IQR] \u22122.2 to 0.4) to 0.1 (IQR \u22121.5 to 1.0); <jats:italic>P<\/jats:italic> &lt; .001 and median from \u22121.0 (IQR \u22121.6 to \u22120.7) to \u22120.8 (IQR \u22121.2 to 0.0); <jats:italic>P =<\/jats:italic> .006 over 2 years, respectively. In patients also treated with tumour necrosis factor\u2010\u03b1 inhibitors (<jats:italic>n<\/jats:italic> = 11), lumbar spine and hip BMD increased significantly (median 2\u2010year change +8.6% [IQR 2.4 to 19.6; <jats:italic>P =<\/jats:italic> .009] and +3.6% [IQR 0.7\u20139.0; <jats:italic>P =<\/jats:italic> .007]). In patients on conventional treatment (<jats:italic>n<\/jats:italic> = 9), lumbar spine BMD increased significantly (median 2\u2010year change +3.6%; IQR 0.7 to 9.0; <jats:italic>P =<\/jats:italic> .011) and no improvement was seen in hip BMD (median \u22120.6%; IQR \u22123.1 to 5.1; <jats:italic>P =<\/jats:italic> .61). Overall, younger AS males with limited spinal radiographic damage showed most improvement in lumbar spine BMD. Four mild radiographic vertebral fractures developed in 3 patients and 1 fracture increased from mild to moderate over 2 years in postmenopausal women and middle\u2010aged men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This explorative observational cohort study in AS showed that 2 years of treatment with bisphosphonates in combination with calcium\/vitamin D supplements significantly improves lumbar spine BMD. Mild radiographic vertebral fractures still occurred.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14431","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T10:55:03Z","timestamp":1591959303000},"page":"644-651","source":"Crossref","is-referenced-by-count":4,"title":["Bone mineral density improves during 2 years of treatment with bisphosphonates in patients with ankylosing spondylitis"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4422-7640","authenticated-orcid":false,"given":"Suzanne","family":"Arends","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology, University of Groningen University Medical Center Groningen  Groningen RB The Netherlands"},{"name":"Rheumatology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freke","family":"Wink","sequence":"additional","affiliation":[{"name":"Rheumatology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Veneberg","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, University of Groningen University Medical Center Groningen  Groningen RB The Netherlands"},{"name":"Rheumatology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"},{"name":"Clinical Pharmacy and Pharmacology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Bos","sequence":"additional","affiliation":[{"name":"Rheumatology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"van Roon","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy and Pharmacology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"},{"name":"Pharmacotherapy, \u2010 Epidemiology and \u2010 Economics, Faculty Science &amp; Engineering University Groningen  Groningen AB The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eveline","family":"van der Veer","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, University of Groningen University Medical Center Groningen  Groningen RB The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Maas","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, University of Groningen University Medical Center Groningen  Groningen RB The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anneke","family":"Spoorenberg","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, University of Groningen University Medical Center Groningen  Groningen RB The Netherlands"},{"name":"Rheumatology Medical Center Leeuwarden  Leeuwarden BR The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000053"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-012-2018-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22158"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22980"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10139"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg256"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.041392"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket321"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204938"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"445","article-title":"Clinical efficacy of oral alendronate in ankylosing spondylitis: a randomised placebo\u2010controlled trial","volume":"35","author":"Coates L","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000010738"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13494"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.084426"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2014.05.008"},{"key":"e_1_2_10_16_1","unstructured":"The International Society for Clinical Densitometry. 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