{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:31:23Z","timestamp":1790238683026,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to monitor the trajectories of antidepressant use during pregnancy and the postpartum period among women chronically treated with antidepressants before their pregnancy, and to assess characteristics associated with each trajectory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cohort study included all pregnant women whose data were included in the General Sample of Beneficiaries (EGB) database affiliated with the French Health Insurance System, from 2009 to 2014. Women were followed up until 6 months after childbirth. Chronic treatment was defined as exposure over the 6\u2010month period preceding pregnancy. A group\u2010based trajectory model (GBMT) was estimated to identify distinctive longitudinal profiles of antidepressant use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 760 women chronically treated with antidepressants before their pregnancy, 55.8% stopped their treatment permanently in the first trimester, 20.4% discontinued it for a minimum of 3 months and resumed it postpartum, and 23.8% maintained it throughout pregnancy and postpartum. No sociodemographic or medical characteristics were associated with any trajectory group. Women who maintained treatment presented more frequent obstetric complications and postpartum psychiatric disorders. Among women who interrupted treatment, prescription of benzodiazepines and anxiolytics decreased initially but rose postpartum to a higher level than before pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregnant women treated with antidepressant require a re\u2010evaluation of psychiatric treatment. It is necessary to pay attention to obstetric complications for severely depressed women. Additionally, as relapse was associated with increased benzodiazepine use, it is important to carefully monitor all women who stop antidepressant treatment during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14449","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T04:01:44Z","timestamp":1596600104000},"page":"965-987","source":"Crossref","is-referenced-by-count":18,"title":["Trajectories of antidepressant drugs during pregnancy: A cohort study from a community\u2010based sample"],"prefix":"10.1111","volume":"87","author":[{"given":"Aur\u00e9lie","family":"Cabaillot","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine G\u00e9n\u00e9rale, UFR de M\u00e9dicine Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"},{"name":"CHU Clermont\u2010Ferrand, Inserm, Neuro\u2010Dol, Service de Pharmacologie m\u00e9dicale, Centres Addictovigilance et Pharmacovigilance, Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA), Institut Analgesia Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bourset","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine G\u00e9n\u00e9rale, UFR de M\u00e9dicine Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mulliez","sequence":"additional","affiliation":[{"name":"D\u00e9l\u00e9gation \u00e0 la recherche clinique et \u00e0 l'innovation CHU Clermont\u2010Ferrand  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Delorme","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand, Inserm, Neuro\u2010Dol, Service de Pharmacologie m\u00e9dicale, Centres Addictovigilance et Pharmacovigilance, Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA), Institut Analgesia Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Orri","sequence":"additional","affiliation":[{"name":"McGill Group for Suicide Studies, Douglas Mental Health University Institute, Department of Psychiatry McGill University  Montr\u00e9al QC Canada"},{"name":"Bordeaux Population Health Research Centre, Inserm U1219 Universit\u00e9 de Bordeaux  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Vicard\u2010Olagne","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine G\u00e9n\u00e9rale, UFR de M\u00e9dicine Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"},{"name":"Npsysydo Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Christine","family":"Zenut","sequence":"additional","affiliation":[{"name":"CHU Clermont\u2010Ferrand, Inserm, Neuro\u2010Dol, Service de Pharmacologie m\u00e9dicale, Centres Addictovigilance et Pharmacovigilance, Observatoire Fran\u00e7ais des M\u00e9dicaments Antalgiques (OFMA), Institut Analgesia Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5054-5805","authenticated-orcid":false,"given":"Marie","family":"Tournier","sequence":"additional","affiliation":[{"name":"Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology Universit\u00e9 de Bordeaux  Bordeaux France"},{"name":"Hospital Charles Perrens  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Gallot","sequence":"additional","affiliation":[{"name":"CNRS 6293, INSERM 1103, GReD, QC G1V 0A6 Clermont\u2010Ferrand; 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