{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:13:46Z","timestamp":1791947626926,"version":"4.3.4"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,3]]},"abstract":"\n Aims<\/jats:title>\n \n Several cases of acute non\u2010infectious cholestatic hepatitis recently appeared in Italy following consumption of\n \n Curcuma longa<\/jats:italic>\n <\/jats:styled-content>\n \u2010containing dietary supplements. The aim of this research was to describe the Tuscan (Italy) cases of acute hepatitis and to compare them with similar cases of hepatotoxicity published in the literature by performing a systematic review.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Records of Tuscan cases of acute hepatitis were obtained from the Italian Phytovigilance system. Each spontaneous report was analysed in order to collect all relevant clinical information of patients and information concerning the\n \n Curcuma longa<\/jats:italic>\n <\/jats:styled-content>\n \u2010containing dietary supplement. Moreover, both the RUCAM and WHO\u2010UMC systems were used to evaluate the causal relationship between the use of dietary supplement and acute hepatitis. A systematic literature review was performed in MEDLINE and Embase and all case\u2010reports and case\u2010series published in English were included.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seven cases of acute hepatitis occurring in Tuscany up to September 2019 are described. In all cases, hepatotoxicity was associated with\n \n Curcuma longa<\/jats:italic>\n <\/jats:styled-content>\n formulations with high bioavailability and high dosage of curcumin\/curcuminoids. The causal relationship was also supported by the\n positive dechallenge<\/jats:italic>\n observed in most cases. In the 23 cases identified through the systematic review, the majority of patients were concomitantly exposed to at least one other medication and 16 of them experienced a\n positive dechallenge.<\/jats:italic>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Within the frame of poorly controlled and regulated products, such as dietary supplements, the evaluation of Italian cases of\n \n Curcuma longa<\/jats:italic>\n <\/jats:styled-content>\n \u2010induced acute hepatitis and the systematic review of literature confirmed the association between\n \n Curcuma longa<\/jats:italic>\n <\/jats:styled-content>\n and liver injury.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bcp.14460","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T03:48:45Z","timestamp":1594612125000},"page":"741-753","source":"Crossref","is-referenced-by-count":74,"title":["Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports"],"prefix":"10.1111","volume":"87","author":[{"given":"Niccol\u00f2","family":"Lombardi","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Crescioli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Maggini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"CERFIT, Research and Innovation Center in Phytotherapy and Integrated Medicine, Referring Center for Phytotherapy, Tuscany Region Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Ippoliti","sequence":"additional","affiliation":[{"name":"National Centre for Drug Research and Evaluation National Institute of Health Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Menniti\u2010Ippolito","sequence":"additional","affiliation":[{"name":"National Centre for Drug Research and Evaluation National Institute of Health Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine University of Florence Florence Italy"},{"name":"CERFIT, Research and Innovation Center in Phytotherapy and Integrated Medicine, Referring Center for Phytotherapy, Tuscany Region Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Brilli","sequence":"additional","affiliation":[{"name":"Toxicology Unit and Poison Centre Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Lanzi","sequence":"additional","affiliation":[{"name":"Toxicology Unit and Poison Centre Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Mannaioni","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence Florence Italy"},{"name":"Toxicology Unit and Poison Centre Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Firenzuoli","sequence":"additional","affiliation":[{"name":"CERFIT, Research and Innovation Center in Phytotherapy and Integrated Medicine, Referring Center for Phytotherapy, Tuscany Region Careggi University Hospital Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-2026","authenticated-orcid":false,"given":"Alfredo","family":"Vannacci","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology University of Florence Florence 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