{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:07:14Z","timestamp":1783116434249,"version":"3.54.6"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the prevalence of potential prescribing issues (PPI) in HIV\u2010infected subjects aged \u226565 years according to the Beers and STOPP\/START criteria and antiretroviral drug\u2013drug interactions (Liverpool website). Secondary objectives were to assess the concordance between Beers and STOPP\/START criteria in our population, and to identify the drugs most frequently involved in PPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional cohort study based on a systematic review of the electronic drug prescriptions confirmed by an interview of 91 HIV\u2010infected patients aged \u226565 years. Discrepancies between prescription criteria were assessed using crosstabs and compared using the \u03c7<jats:sup>2<\/jats:sup> test or Fisher exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 72.1 (5.6) years, 75.8% had \u22653 comorbidities and 59.3% polypharmacy. PPI were identified in 87.9%: 71.4% by STOPP\/START and 45.1% by Beers. Comparing both criteria, 56.9% of PPI by STOPP\/START were detected by Beers, while 92.5% of those detected by the Beers criteria were detected by STOPP\/START (<jats:italic>P<\/jats:italic> &lt; .001). Amber\/red flag interactions between antiretrovirals and comedications were found in 45.1%: 3 severe (red) in 2 patients (2.2%). The most frequent drugs involved in PPI were benzodiazepines (&gt;30%). Cobicistat was the drug most frequently involved in potential interactions (42.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of PPI among older HIV\u2010infected persons gives cause for concern, as it is almost 90%. Optimization strategies, including a critical review of the treatment plan, should be implemented in clinical routine by a multidisciplinary team, in particular in patients with multiple comorbidities and polypharmacy. The STOPP\/START criteria seem to detect more PPI, mainly for European populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bcp.14513","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T14:31:23Z","timestamp":1598884283000},"page":"1310-1317","source":"Crossref","is-referenced-by-count":14,"title":["Potential prescribing issues among older HIV\u2010infected subjects in a Mediterranean cohort: Does the current prevalence give cause for concern?"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5406-1875","authenticated-orcid":false,"given":"Cora","family":"Loste","sequence":"first","affiliation":[{"name":"Infectious Diseases Department &amp; Lluita contra la Sida Foundation Hospital Universitari Germans Trias i Pujol, Badalona; Universitat Aut\u00f2noma de Barcelona  Spain"},{"name":"Chair in Infectious Diseases and Immunity, Centre for Health and Social Care Research (CESS), Faculty of Medicine University of Vic 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