{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:57:28Z","timestamp":1791593848018,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brit J Clinical Pharma"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p>Eculizumab is known to cross the placenta to a limited degree, but recently therapeutic drug levels in cord blood were found in a single case. We report maternal, cord and placental levels of unbound eculizumab, C5 and C5\u2010eculizumab in two pregnancies of a paroxysmal nocturnal haemoglobinuria patient who received 900 mg eculizumab every 2 weeks. In both pregnancies, cord blood concentrations of unbound eculizumab were below 4 \u03bcg\/mL, while C5\u2010eculizumab levels were 22 and 26 \u03bcg\/mL, suggesting that a considerable fraction of C5 was blocked in the newborn. Concentrations in each placenta of unbound eculizumab were 41 \u00b1 3 and 45 \u00b1 4 \u03bcg\/g tissue, of C5\u2010eculizumab 19 \u00b1 2 and 32 \u00b1 3 \u03bcg\/g, and of C5 20 \u00b1 3 and 30 \u00b1 2 \u03bcg\/g (mean \u00b1 SD, in three tissue samples per placenta). Placental levels of unbound eculizumab were higher than those of C5\u2010eculizumab complexes, while maternal concentrations were approximately equal, suggesting selective transport of unbound eculizumab across the placenta.<\/jats:p>","DOI":"10.1111\/bcp.14565","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T20:28:19Z","timestamp":1601324899000},"page":"2128-2131","source":"Crossref","is-referenced-by-count":10,"title":["Placental disposition of eculizumab, C5 and C5\u2010eculizumab in two pregnancies of a woman with paroxysmal nocturnal haemoglobinuria"],"prefix":"10.1111","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5503-3112","authenticated-orcid":false,"given":"Gaby A.M.","family":"Eliesen","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Radboud Institute for Molecular Life Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"van Drongelen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud Institute for Health Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra H.H.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Radboud Institute for Molecular Life Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Sarlea","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Amalia Children's Hospital Radboud Institute for Molecular Life Sciences  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier W.H.","family":"van der Heijden","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud 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